【作者】 杨青；

【导师】 莫锦秋； 牛志宏；

【作者基本信息】 上海交通大学 ， 机械工程， 2018， 硕士

【摘要】 针对目前体外胚胎移植手术中胚胎种植率过低的现象,提出基于人体子宫腔几何模型、体外胚胎移植过程数值仿真以及体外胚胎移植模拟实验验证的解决方案。结合几何尺寸,运用Ansys Fluent软件建立了基于多相流离散相仿真模型,得到最佳移植液总量以及注射完移植液后子宫腔模型内部压力分布云图。仿真了不同水平的三参数组合下(移植管端部与宫底距离、注射时间、子宫角度)模拟的人类胚胎进入模拟宫腔后运动轨迹以及最终的沉积位置。综合分析仿真结果得出了最佳子宫角度区间、最佳注射时间以及最佳移植管端部与宫底距离,以及子宫角度对沉积位置有影响的原因是不同的子宫角度会引起重力不同。基于数值仿真的基本结论,搭建了体外胚胎移植实验系统平台,实物测量了在注入胚胎移植液后人体子宫腔和实物子宫腔模型内部压力情况,均符合数值仿真得到的子宫腔模型内部压力。在不同参数配合下,进行体外胚胎移植实验,分析最终胚胎的沉积位置,并与数值仿真的结果进行比较,进一步确定了最佳参数。从而对提高体外胚胎移植临床妊娠成功率有重要指导作用。更多还原

【Abstract】 Aiming at the status quo of low rate of embryo implantation in in-vitro embryo transfer,a solution based on geometric model of human uterine cavity、numerical simulation of in-vitro embryo transfer and in-vitro embryo transfer simulation experiment has been proposed.Combined with geometrical dimension and fluid mechanics,we used Ansys Fluent to establish the discrete phase simulation model based on multi-phase flow to get the optimal total volume of transplanted fluid and the pressure distribution map of the intrauterine cavity model after the transplanted fluid was injected.The human embryos simulated by different levels of three-parameter combination(the distance between the end of transplantation tube and the bottom of the uterus、injection time and uterine angle)were simulated to research its movement path and the final deposition location in uterine.The best uterine angle interval,the best injection time and the distance between the end of transplantation tube and the bottom of the uterus were obtained by comprehensive analysis of the simulation results,and different uterine angles cause different deposition position is due to different gravities.Based on the basic conclusion of numerical simulation,we set up a platform of in-vitro embryo transfer experiment system to measure the pressure inside the human uterine cavity and in-kind internal pressure of uterine cavity model after the embryo implantation fluid was injected,which were consistent with the pressure inside the uterine cavity model by numerical simulation.Under the condition of different parameters,we carried out in-vitro embryo transfer experiment,analyzed the final deposition position of embryo in uterine,and compared with the result of numerical simulation and further determined the best parameters of each factor.The result and conclusion have an important guiding significance in improving the success rate of clinical pregnancy in in-vitro embryo transfer.更多还原