【作者】 李帅；

【导师】 邓斌； 刘宇；

【作者基本信息】 天津大学 ， 控制工程（专业学位）， 2018， 硕士

【摘要】 无创式脑调制技术已经成为神经精神疾病诊断和治疗的有效手段,其中经颅磁刺激技术以其非侵入式的特点得到了广泛的应用。虽然各种经颅磁刺激形式被提出,但是相应的刺激装置的设计则落后于理论研究,且目前的刺激装置相对简单,无法满足临床需要。因此,本文从刺激参数可灵活调节的角度对经颅磁刺激系统进行研究。首先,本文提出的多参数可调经颅磁刺激系统中,可调节参数包括线圈中电流形式、刺激强度以及刺激线圈。详细叙述了系统的整体结构,基于电磁场理论,实现对单向、双向、簇状刺激电流波形的设计,并给出相应电路仿真来验证方案可行性。同时,对于多线圈阵列的控制也给出了简要的设计方案。其次,通过硬件电路实现磁刺激系统的设计,包括电源电路、控制电路、逆变电路和线圈控制电路,并给出了电路中具体的参数选取,基于设计的刺激电路,给出相应的实验结果并与电路仿真进行对比分析。最后,基于有限元分析方法构建了线圈和头颅模型,给出了模型参数,定义了刺激效果的评价指标:刺激深度和聚焦度。对两种商用线圈的感应电场分布以及刺激效果做了简要的对比分析,进而着重分析了刺激线圈直径和角度的变化对刺激效果的影响,定量和定性地分析了变化过程中的规律。本文从刺激电流波形设计、电路仿真、硬件系统实现以及电磁场分布角度给出磁刺激装置的设计与理论分析,为新型经颅磁刺激装置的设计和应用提供了新的思路。更多还原

【Abstract】 Non-invasive brain modulation has become an effective means of diagnosis and treatment of neuropsychiatric disorders.Transcranial magnetic stimulation technology has been widely used for its non-invasive features.Although various forms of stimulation have been proposed,the design of the corresponding stimulation device lags behind the theoretical research,and the current device is relatively simple and cannot meet the clinical needs.Therefore,this paper developed a new stimulation device from the perspective of designing flexible adjustment of stimulation parameters.First of all,in the stimulation system proposed in this paper,the adjustable parameters included the current form in the coil,the stimulation intensity and the stimulation coil.The overall structure of the system was described in detail.Based on the theory of electromagnetic field,the realization of monophasic,biphasic or burst stimulating currents,the adjustment of stimulus intensity and the control of coil selection were all given the corresponding circuit simulations to verify the feasibility of the scheme.At the same time,the control of multi-coil array also gives a brief design.Secondly,the design of the magnetic stimulation system was realized by the hardware circuit,including the power supply circuit,the control circuit,the inverter circuit and the coil control circuit.The specific parameters of the circuit were all given in this paper.Based on the designed stimulation circuit,the corresponding experimental results was compared with the results of circuit simulation.Finally,the coils and brain models were constructed based on the finite element analysis method.The model parameters were given and the evaluation criteria for stimulus effects were defined: stimulus depth and focus.The inductive electric field distribution and the stimulating effect of two kinds of commercial coils were analyzed briefly.Then the influence of the variation of the diameter and angle of the stimulating coil on the stimulating effect was analyzed emphatically.The regularity in the changing process was quantitatively and qualitatively analyzed.This paper gives the design and theoretical analysis of the magnetic stimulation device from the aspects of stimulating current waveform design,circuit simulation,hardware system realization,electromagnetic field distribution,which provides a new idea for the design and application of new transcranial magnetic stimulation device.更多还原