【作者】 张帆；

【导师】 刘学军；

【作者基本信息】 山西医科大学 ， 内科学（专业学位）， 2019， 硕士

【摘要】 目的:探讨体质指数正常和肥胖OSA与血脂异常的关系,为不同类型OSA的防治提供思路。方法:采取病例对照研究,收集2015年1月至2017年12月在山西医科大学第一医院老年病科行多导睡眠监测(PSG)的存在夜间打鼾的病人,收集相关病史资料、血生化指标以及多导睡眠监测结果。根据血脂水平将病人分为血脂异常组和血脂正常组,分析引起血脂异常的影响因素。根据体质指数的不同将病人分为正常体重组和超重(肥胖)组,分别比较两组中OSA病人和对照组的一般资料及血脂水平,并行多因素Logistic回归分析明确不同BMI的OSA病人中血脂异常与OSA的关系。结果:1.患者的年龄、体重、AHI、BMI在血脂异常和血脂正常两组中分布有差异,P<0.05。2.多因素Logistic回归分析显示,BMI(OR=1.190,95%CI:1.055-1.343)和AHI(OR=1.075,95%CI:1.021-1.132)是血脂异常的危险因素。3.与正常体重+单纯鼾症相比,正常体重+OSA的HDL-C水平较低(P<0.05);超重(肥胖)+OSA与超重(肥胖)+单纯鼾症之间各因素差异无统计学意义。4.正常体重OSA组AHI(OR=1.376,95%CI:1.091-1.735)是血脂异常的危险因素;而在超重(肥胖)OSA组中,未发现AHI与血脂异常的发病风险有关联。结论:肥胖和OSA均与血脂异常相关。正常体重的OSA病人,OSA与血脂异常相关;伴有肥胖的OSA病人,未发现OSA与血脂水平异常相关。更多还原

【Abstract】 Objective:To explore the relationship between normal body mass index and obese OSA and dyslipidemia,and provide ideas for the prevention and treatment of different types of OSA.Methods:A case-control study was conducted to collect patients with snoring in the presence of polysomnography(PSG)in the Department of Geriatrics,First Hospital of Shanxi Medical University from January 2015 to December 2017,collecting relevant medical history data,blood biochemical indicators,and more.Guide sleep monitoring results.According to the level of blood lipids,the patients were divided into dyslipidemia group and normal blood lipid group,and the influencing factors of dyslipidemia were analyzed.According to the difference of body mass index,the patients were divided into normal body reorganization and overweight(obesity)group.The general data and blood lipid levels of OSA patients and control group were compared between the two groups.Multivariate logistic regression analysis was used to identify the relationship between blood lipids anomalies and OSA in OSA patients with different BMI.Results:1.The age,weight,AHI,and BMI of the patients were different in the dyslipidemiaand normal blood lipid levels,P<0.05.2.Multivariate logistic regression analysis showed that BMI(OR=1.190,95% CI:1.055-1.343)and AHI(OR=1.075,95% CI: 1.021-1.132)were risk factors for dyslipidemia.3.Compared with normal weight + simple snoring,the normal body weight + OSA HDL-C level was lower(P <0.05);there was no statistical difference between overweight(obesity)+ OSA and overweight(obesity)+ simple snoring.Learning meaning.4.Normal weight OSA group AHI(OR=1.376,95% CI: 1.091-1.735)was a risk factor for dyslipidemia;in the overweight(obese)OSA group,AHI was not associated with the risk of dyslipidemia.Conclusion:Both obesity and OSA are associated with dyslipidemia.In normal-weight OSA patients,OSA is associated with dyslipidemia;in OSA patients with obesity,no OSA is associated with abnormal blood lipid levels.更多还原