【作者】 王斌；

【导师】 许小凤；

【作者基本信息】 南京中医药大学 ， 中医妇科学（专业学位）， 2019， 硕士

【摘要】 目的:调查苏州地区不孕不育患病率、分析苏州地区不孕不育发病相关因素,制定不孕不育预防对策,开展生殖健康科普,造福育龄妇女。方法:本研究为描述性研究,于2017年12月～2019年2月对苏州地区的育龄夫妇进行分层抽样和随机抽样结合调查。在苏州10个市、区(姑苏区、工业园区、高新区、相城区、吴中区、吴江区、昆山市、常熟市、太仓市、张家港市)开展苏州地区已婚育龄期妇女(20-49岁)不孕不育相关发病因素调查。现场调查总人数约5000人,获取有效问卷3549份;网络渠道有效问卷5771份,获取总有效问卷9320份,得到总样本量9320。利用软件SPSS 25.0进行频率分析或定类数据进行基本描述,运用卡方检验分析单因素与不孕不育发病之间相关性。结果:(1)苏州地区不孕不育患病率为16.36%,原发性不孕率为3.27%,继发性不孕率1 3.09%;(2)苏州地区不孕不育发病相关因素:双方年龄、结婚年限、妇科疾病(多囊卵巢综合征、卵巢早衰、子宫内膜异位症、痛经、复发性流产)、月经(周期、经量)、生育、双方体重、女方睡眠、女方小便、女方身体健康状况、女方饮食(清淡、油腻)、女方情绪(开朗、乐观、愉悦、忧伤、多虑、急躁、易怒)、女方人际关系(同事关系、婆媳关系)、双方文化程度、双方职业、家庭收入、性生活频率、性生活满意度和不孕症的发生有相关性(P<0.01)。与男方精子质量异常相关的因素有:工作环境(高温、辐射)(P<0.01);(3)苏州地区不孕症中医证候分型:“肾气亏虚证”占比最大28.1%,其次是“血瘀阻滞证”16%。结论:1、苏州地区不孕不育患病率为16.36%。2、苏州地区不孕不育发病受生物学因素、社会学因素和环境因素影响,(1)生物学因素:年龄、妇科疾病、月经、精子质量、生育史、体重、睡眠质量等;(2)社会学因素:饮食、情绪、文化程度、职业、家庭收入等;(3)环境因素:高温、辐射。3、苏州地区不孕不育中医证候分型主要为肾气亏虚证、血瘀阻滞证。4、针对发病相关因素,开展对苏州地区育龄夫妇的生殖健康教育科普。更多还原

【Abstract】 Objective:To investigate the related factors of infertility in Suzhou,to explore the prevalence of infertility in Suzhou,to analyze the related factors of infertility in Suzhou,to formulate the preventive measures of infertility,and to carry out the popularization of reproductive health science for the benefit of women of childbearing age.Methods:This study was a descriptive study.From December 2017 to February 2019,a stratified and random sampling survey was conducted among couples of childbearing age in Suzhou.In 10 cities and districts of Suzhou(Gusu District,Industrial Park,High-tech Zone,Xiangcheng District,Wuzhong District,Wujiang District,Kunshan City,Changshu City,Taicang City,Zhangjiagang City),we conducted a survey on the related factors of infertility among married women of childbearing age(20-49 years old)in Suzhou.The total number of on-site surveys is about 5000 people,and 3549 valid questionnaires are obtained;5771 valid questionnaires are obtained through network channels,and 9320 valid questionnaires are obtained,and the total sample size is 9320.The software SPSS 25.0 was used to carry out frequency analysis or categorization data,and chi-square test was used to analyze the correlation between single factor and the incidence of infertility.Results:(1)The prevalence of infertility in Suzhou was 16.36%,the primary infertility rate was 3.27%,and the secondary infertility rate was 13.09%;(2)Relevant factors of infertility in Suzhou include age,marriage years,gynecological diseases(polycystic ovary syndrome,premature ovarian failure,endometriosis,dysmenorrhea,recurrent abortion),menstruation(cycle,menstrual volume),fertility,weight of both sides,female sleep,urinary system,female health status,female diet(light,greasy),female mood(Open,optimistic,pleasant,sad,worried,impatient,irritable,female interpersonal relationship(colleague relationship,mother-in-law relationship),education level,occupation,family income,frequency of sexual life,sexual satisfaction a:nd infertility were correlated(P<0.01).The factors related to abnormal sperm quality were:working environment(high temperature,radiation)(P<0.01);(3)TCM syndrome classification of infertility in Suzhou:kidney-qi deficiency syndrome accounted for the largest 28.1%,followed by blood stasis block syndrome 16%.Conclusion:1.The prevalence of infertility in Suzhou was 16.36%.2.The incidence of infertility in Suzhou is influenced by biological factors,sociological factors and environmental factors.(1)Biological factors:age,gynecological diseases,menstruation,sperm quality,reproductive history,weight,sleep quality,etc.(2)Sociological factors:diet,mood,educational level,occupation,family income,etc.(3)Environmental factors:high temperature,radiation.3.The TCM syndromes of infertility in Suzhou are mainly kidney-qi deficiency syndrome and blood stasis blocking syndrome.4.In view of the related factors of the disease,we should carry out scientific popularization of reproductive health education for couples of childbearing age in Suzhou.更多还原