【作者】 赵丽丽；

【导师】 任淑萍；

【作者基本信息】 吉林大学 ， 公共卫生硕士（专业学位）， 2018， 硕士

【摘要】 研究目的:研究绥化市某三甲医院出现妊娠期高血压疾病患者的临床资料,分析影响妊娠期高血压疾病患者的相关危险因素。研究方法:选取2014年3月-2017年12月期间绥化市某三甲医院收治并分娩的236例妊娠期高血压疾病住院患者作为病例组,并将同时期产检正常的236例健康孕妇作为对照组。分析两组患者的临床资料,并由医护人员采用查阅病历的方式提取患者相关信息。采用Logistic回归分析对病例患者进行单因素和多因素回归分析,筛选妊娠期高血压疾病的相关危险因素。研究结果:1.在一般资料的比较方面,病例组与对照组在年龄、BMI、规范产检和双胎等数据比较中,差异均有统计学意义(P<0.05);2.在分娩年龄方面的比较发现,对照组≥35岁的有20例,比例为8.47%,妊娠期高血压疾病孕妇组年龄≥35岁的有23例,比例为9.75%,两组孕妇分娩年龄组成比相比较差异具有统计学意义(P<0.05);3.在分娩孕周(27)37周方面的比较发现,对照组(27)37周的有50例,比例为21.19%,妊娠期高血压疾病孕妇组(27)37周的有80例,比例为33.9%,说明妊娠高血压患者分娩出现分娩孕周不足37周的比率高于健康孕妇,差异具有统计学意义(P<0.05);4.在胎儿体重(27)2.5kg方面的比较发现,妊娠期高血压疾病孕妇组为46例,占比为19.49%,对照组有10例,占比为4.24%,说明妊娠高血压患者分娩出现胎儿低重量的比率高于健康孕妇,差异具有统计学意义(P<0.05);5.在临床检验指标比较方面,病例组白细胞、淋巴细胞、中性粒细胞、纤维蛋白原高于对照组,血小板、凝血酶原时间、凝血酶时间低于对照组,差异具有统计学意义(P<0.05);6.年龄≥35岁、BMI≥25kg/m~2、具有高血压家族史、未规范产检是妊娠期高血压疾病的危险因素。研究结论:(1)妊娠期高血压疾病能够增加患者发生早产和新生儿低体重的可能性,具体表现为妊娠高血压疾病患者分娩出现分娩孕周不足37周的比率高于健康孕妇,妊娠高血压患者分娩出现胎儿低重量的比率高于健康孕妇;(2)妊娠期高血压患者白细胞、淋巴细胞、中性粒细胞、纤维蛋白原高于对照组,血小板、凝血酶原时间、凝血酶时间低于对照组;(3)年龄≥35岁、孕前体重指数≥25kg/m~2、具有高血压家族史、未规范产检是妊娠期高血压疾病的危险因素。更多还原

【Abstract】 Objective:To study the clinical data of patients with hypertensive disease during pregnancy and to analyze the related risk factors of hypertension during pregnancy.Methods:A total of 236 hospitalized patients with hypertensive disorder complicating pregnancy were enrolled in our hospital from March 2014 to December 2017,and 236 healthy pregnant women with normal birth control were used as control group.The clinical data of the two groups of patients were analyzed,and the medical staff used the questionnaire to investigate the patients.Logistic regression analysis was used to analyze the risk factors of hypertensive disorder complicating pregnancy in patients in the study group by univariate and multivariate regression analysis..Results:1.In the general data comparison,there were significant differences between the study group and the control group in age,BMI,education,standardized birth examination and twin pregnancy data(P < 0.05).2.There were 20 cases(8.47%)in the control group and 23 cases(9.7575%)in the pregnant women with gestational hypertension ≥ 35 years old.There was significant difference in the composition of delivery age between the two groups(P < 0.05).3.The comparison of gestational weeks(37 weeks)showed that there were 50 cases(21.19%)in the control group(37 weeks)and 80 cases(33.9%)in the pregnant women with hypertension complicating pregnancy(37 weeks).The results showed that the rate of gestational age less than 37 weeks in pregnancy with hypertension was significantly higher than that in healthy pregnant women(P < 0.05).4.In comparison of fetal weight(2.5kg),46 cases(19.49%)were found in gestational hypertension group,and 10 cases(4.24%)in control group.The results showed that the rate of fetal low weight in pregnancy with hypertension was significantly higher than that in healthy pregnant women(P < 0.05).5.There was statistical significance in the comparison of clinical test indexes(P < 0.05).6.By logistic regression analysis,the main influencing factors of hypertension complicating pregnancy were age,BMI value,family history of hypertension,standardized birth examination and emotional factors.Conclusion:(1)Pregnancy-induced hypertension can increase the possibility of premature delivery and low birth weight.Specifically,the incidence of less than 37 weeks of gestation in patients with pregnancy-induced hypertension is higher than that in healthy pregnant women,and the incidence of low fetal weight in patients with pregnancy-induced hypertension is higher than that in healthy pregnant women.(2)Leukocyte,lymphocyte,neutrophil and fibrinogen in patients with gestational hypertension were higher than those in the control group,while platelet,prothrombin time and thrombin time were lower than those in the control group.(3)Age(> 35 years old),pre-pregnancy body mass index(> 25kg/m2),family history of hypertension,and non-standardized obstetric examination were risk factors for hypertensive disorders in pregnancy.更多还原