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TACE联合微波消融对原发性肝癌治疗的疗效评价
Therapeutic Evaluation of TACE Combination Microwave Ablation for Treatment of Primary Hepatocellular Carcinoma
【作者】 张帆；
【导师】 冯对平；
【作者基本信息】 山西医科大学 ， 影像医学与核医学（专业学位）， 2018， 硕士
【摘要】 研究目的:评价经导管动脉化疗栓塞(Transcatheter arterial chemoembolization,TACE)与TACE联合微波消融对于原发性肝癌(I、II期)治疗的有效性及安全性。研究方法:收集2016年2月~2017年8月41例原发性肝癌患者的临床治疗资料,其中TACE 24例,TACE联合微波消融17例。分析两种手术术前、术后1周肝功能等的变化,术后1月淋巴细胞亚群等改变,并比较12个月无进展生存期。研究结果:两组患者术前、术后肝功能变化无统计学意义(P>0.05),两组术后CD4~+均高于术前,差异具有统计学意义(P<0.05),联合组肿瘤无进展生存期明显高于单纯组(P<0.05)。结论:TACE联合微波消融能有效地控制原发性肝癌患者早期肝内肿瘤进展,并且能提高患者免疫功能。
【Abstract】 Objective:To evaluate the safety and efficacy of TACE combined with MWA versus TACE alone for treatment of primary hepatocellular carcinoma(I、II stage).Methods:The clinical data of 41 patients with primary hepatocellular carcinoma were retrospectively collected from February 2016 to August 2017,including 24 cases of pure TACE,and 17 cases of TACE combined with microwave ablation.The changes of liver function and lymphocyte subgroup were analyzed before and after the procedures.Results:Liver function show no statistical significance between two groups preoperative and postoperative(P>0.05).The number of CD4~+T cells postoperative from two groups was significantly higher than that of preoperative(P<0.05).PFS of combined treatment group was significantly higher than single treatment group(P<0.05).Conclusion:TACE combined with microwave ablation can significantly improve the tumor progress and immune function of patients with early stage PHC.