【作者】 罗琴；

【导师】 常克；

【作者基本信息】 成都中医药大学 ， 中医儿科学， 2018， 硕士

【摘要】 目的:观察咳嗽1号方治疗小儿喉源性咳嗽痰热搏结咽喉证的临床疗效,为中医药治疗小儿喉源性咳嗽痰热搏结咽喉证提供临床依据,丰富中医药治疗小儿喉源性咳嗽的治疗思路与方法。方法:本次临床研究收集于成都市中医药大学附属医院儿科门诊自2017年1月至2018年1月期间就诊患儿,共70例,属于喉源性咳嗽痰热搏结咽喉证型的患儿,按照对照法的试验设计原则分为两组,每组各35例。治疗组35例予以“咳嗽1号方”加减,对照组35例予以“小儿咽扁颗粒”口服,治疗一个疗程后,对两组患儿治疗前后的临床主、次要症状及咽部体征的情况进行评分,再将收集的资料进行整理,分别运用统计软件进行统计学分析和结果分析。结果:(1)综合疗效评价:治疗组临床痊愈的有6人,显效的有18人,有效的有8人,无效的有3人,总有效率为91.42%;对照组的患儿经过治疗后痊愈的有1人,显效的有6人,有效的有18人,无效的有10人,总有效率为71.42%。经非参数检验,治疗组的治疗效果优于对照组。(2)主要症状疗效评价:治疗组在改善咳嗽、咽痒、咽干主要症状方面,治疗组疗效优于对照组,经比较有统计学意义。(3)次症疗效评价:治疗组在改善咯痰、咽部异物感症状方面,疗效优于对照组,经比较有统计学意义。(4)咽部体征疗效评价:治疗结束后,治疗组在改善“咽后壁淋巴滤泡增生”体征方面的疗效优于对照组。(5)安全性评价:两组共70例患儿在治疗过程中,均未发现有任何不良反应,安全性评价为1级。结论:咳嗽1号方治疗喉源性咳嗽痰热搏结咽喉证具有良好疗效,能够有效的控制患儿临床主、次要症状,改善患儿咽部充血、咽后壁淋巴滤泡增生等体征,运用咳嗽1号方治疗喉源性咳嗽痰热搏结咽喉证的疗效明显优于对照组。更多还原

【Abstract】 Objective: Research curative effect of cough 1 Decoction on childrens’ s laryngeal cough caused by phlegm-heat syndrome.To further explore the pathogenesis and treatment of TCM pediatric laryngeal cough the study provides clinical basis for TCM treatment of pediatric laryngeal cough throat phlegm-heat syndrome.Methods:The clinical study of 70 cases were collected from the Chengdu University of TCM Affiliated Hospital Outpatient Department of Pediatrics from January 2017 to January 2018 during the visit,which belongs to the throat phlegm-heat syndromes of laryngeal cough in children,according to the design principle of randomized divided into two groups,35 cases in each group.The treatment group of 35 cases treated with " Kesou1 Hao Fang",control group 35 cases were treated with" Xiao’ er yan bian particle",a course of 7 days,were evaluated before and after treatment in two groups of children with clinical primary and secondary symptoms and signs,tongue pharynx,and then collected data collated respectively,statistical analysis and result analysis using statistical software.Results:(1)the comprehensive curative effect evaluation: treatment group clinical recovery in 6,effective in 18,effective 8,invalid 3,the total effective rate was 91.24%;the control group after treatment in children with recovery of 1,effective in 6,effective 18 people,10 were invalid,the total effective rate was 71.24%.The non parametric test,the treatment group was better than the control group.(2)evaluation of the main symptoms: the treatment group and the control group in the treatment of cough,pharyngeal itching of the main symptoms,compared with a significant statistical significance,the treatment group was better than the control group.(3)times clinical evaluation: the treatment group in improving pharyngeal foreign body sensation,phlegm,throat symptoms,curative effect is better than that of control group.(4)evaluation of pharyngeal signs and tongue effect: after treatment,the treatment group in improving the retropharyngeal lymph follicle hyperplasia "" pharynx "" tongue "signs and the effect is better than the control group.(5)safety evaluation: there were no adverse reactions in the treatment of the patients in the 70 groups,and the safety evaluation of the patients in the two groups was grade 1.Conclusion: cough 1 decoction has good curative effect on laryngeal cough throat dampness syndrome,can effectively control the clinical major and secondary symptoms,improve children throat congestion,pharyngeal lymphoid follicular hyperplasia and other signs,using the effect of cough 1 Decoction in the treatment of laryngeal cough and throat phlegm-heat syndrome was significantly better than the control group.更多还原