【作者】 李建英；

【导师】 刘改芳；

【作者基本信息】 河北医科大学 ， 内科学（专业学位）， 2018， 硕士

【摘要】 幽门螺杆菌(Helicobacter pylori,H.pylori)的感染率一直居高不下,全球一半的人群存在感染,目前MaastrichtⅤ共识及京都共识均要求对H.pylori感染患者行根除治疗,除非有抗衡因素的存在。推荐根除H.pylori的治疗方案中必须包含铋剂、质子泵抑制剂(proton pump inhibitors,P PIs)和两种不同的抗菌药,且优先考虑耐药率低的抗生素,早晚各服用1次,总疗程是10-14天。但这种四联疗法需口服大剂量抗菌药物和PPIs,结果可致正常胃肠道菌群紊乱,破坏具有保护作用的天然生物屏障,扰乱机体免疫系统等。本文就根除H.pylori治疗对胃肠道菌群短期和长期影响以及益生菌在根除H.pylori治疗中作用的研究进展进行综述。更多还原

【Abstract】 The infection rate of Helicobacter pylori(H.pylori)remains high and half of the world’s population is infected.Resently,it has been recommended that H.pylori infected individuals should be given eradication therapy unless there are competing considerations both in Maastricht V and Kyoto consensus.The recommended regimens for H.pylori eradication should include bismuth,proton pump inhibitors(PPIs)and two different kinds of antibiotics with lower drug resistance.These drugs should be taken twice daily both in the morning and evening,and the total course of treatment should be 10 to 14 days.However,the quadruple therapy includes high-dose antibiotics and PPIs,which may lead to disorders of normal gastrointestinal flora,destruction of natural protective barrier,and disturbance of the body’s immune system.This article reviews research progress of the short and long term influence on gastrointestinal flora and the role of probiotics in the eradication of H.pylori therapy.更多还原