【作者】 李静；

【导师】 左小芹；

【作者基本信息】 青海大学 ， 全科医学， 2018， 硕士

【摘要】 目的:探讨MPV与T2DM合并颈动脉硬化的关系。方法:选择2016年11月-2017年11月在青海大学附属医院内分泌科及全科医学科就诊的T2DM患者123例为研究对象。1、将病例分为单纯糖尿病组和糖尿病合并颈动脉硬化组,比较两组之间年龄、腰围、血小板参数等指标的差异;2、根据CIMT结果将患者分为颈动脉内膜正常组(A组),内膜增厚组(B组),斑块组(C组),比较三组之间年龄、腰围、血脂四项、血小板参数及糖化血红蛋白(Hb A1c)水平等因素的差异;3、根据Hb A1c水平将患者分为两组,Hb A1c正常组(<7%),Hb A1c升高组(≥7%),比较两组间CIMT和血小板参数的差异;4、CIMT、MPV与其他因素的相关性分析;5、根据有无斑块将颈动脉硬化组分为有斑组和无斑组,两组间比较用独立样本t检验,并行Logistic回归分析影响斑块形成的危险因素。结果:1、单纯糖尿病组和糖尿病合并颈动脉硬化组之间腰围、BMI、TC、TG、MPV、PDW、CIMT的差异具有统计学意义(P<0.05);2、CIMT三组之间、TC、TG、MPV、PDW、CIMT的差异具有统计学意义(P<0.05);3、Hb A1c分组两组间CIMT、MPV、PDW的差异具有统计学意义(P<0.05);4、CIMT与TC、TG、Hb A1c、MPV、PDW均呈正相关;MPV与腰围、BMI、DBP、TC、TG、FPG、Hb A1c、PDW、CIMT呈正相关;5、年龄、TG、MPV是T2DM患者颈动脉斑块形成的危险因素。结论:MPV是T2DM患者颈动脉斑块形成的危险因素,表明MPV可能是糖尿病患者颈动脉硬化程度的预测因子。更多还原

【Abstract】 Objective: To study the correlation between MPV and type 2 diabetes with carotid atherosclerosis.Methods : 123 cases of T2 DM patients in Department of Endocrinology and General Department of medicine in Affiliated Hospital of Qinghai University,November 2016-2017,were selected as the research subjects.(1)Patients were divided into simple diabetes group and diabetes with carotid atherosclerosis group.The difference of age and platelet parameters between the two groups were compared.(2)According to CIMT results,the patients were divided into normal carotid artery group(group A),intimal thickening group(group B)and plaque group(group C).The differences of age,blood lipid four items,platelet parameters and glycosylated hemoglobin(Hb A1c)level between the three groups were compared.(3)According to the level of Hb A1 c patients were divided into two groups,Hb A1 c < 7%,Hb A1 c ≥7%,the difference between the two groups of CIMT and platelet parameters were compared.(4)Correlation analysis of CIMT and MPV with other factors.(5)According to plaque,patients were divided into plaque group and spotless group.The independent samples t test was used in the two groups,and Logistic regression analysis was used to analyze the risk factors of plaque.Data were analyzed using SPSS 17.0.Results:(1)The difference of age and MPV between diabetic group and diabetes with carotid artery sclerosis group was statistically significant(P < 0.05).(2)The differences of MPV,age,uric acid,triglyceride and cholesterol were statistically significant between the three groups of CIMT(P < 0.05).(3)The difference of CIMT and MPV between the two groups of the Hb A1 c was statistically significant(P < 0.05).(4)CIMT was positively correlated with age,TC,TG,MPV and PDW(P<0.05);MPV was positively related to UA,TC,TG,CIMT(P<0.05).(5)Age,TG,MPV,and CIMT are the risk factors of carotid plaque in T2DM patients.Conclusion: MPV is a risk factor for the formation of carotid artery plaque in T2 DM patients,suggesting that MPV has a predictive value for the T2 DM macrovascular disease.更多还原