【作者】 杨峰；

【导师】 张卫星；

【作者基本信息】 郑州大学 ， 外科学（泌尿外科）（专业学位）， 2018， 硕士

【摘要】 目的:随着人民群众生活水平的提高,人民群众对生活质量的要求也越来越高。而现在男性健康被重视的程度也相应的得高了明显的提高。阴茎勃起功能障碍是男性健康中最为复杂的一种障碍。目前已经明确NO-cGMP通路对于男性阴茎勃起中具有重要作用。NO的产生主要由三种不同的酶催化产生。而其中eNOS及iNOS主要存在于正常组织中,而iNOS主要在受到相关炎症介质伺候后才产生。同样的,有大量研究表明,睾酮在在阴茎勃起中也具有重要作用。现探讨一氧化氮、诱导型一氧化氮合酶、睾酮在以EHS勃起硬度分级分组的情况下,分析各组之间的关系。方法:通过在门诊收集患者病人信息,根据EHS调查信息,将患者按照EHS勃起功能由差到好的四个级别分别分成A组,B组,C组及正常对照组,然后分别采集静脉血,进行一氧化氮,诱导型一氧化氮合酶,及睾酮值的检查,比较不同的EHS分组中,三者指标有无相关性。结果:在阴茎勃起功能EHS等级的中,勃起功能1级的静脉血中NO的值与正常对照组具有统计学意义。而iNOS中,A组与C组级及A组与对照组之间iNOS含量具有统计学差异(P<0.05)。在各组中,血清睾酮值比较没有统计学意义。结论NO及iNOS与阴茎勃起功能之间存在相关性,且勃起功能差的患者中,NO含量低而iNOS含量高。在排除了年龄及内分泌性疾病后,器质性勃起功能障碍患者与正常对照组之间组睾酮值无统计学差异。更多还原

【Abstract】 BackgroundWith the improvement of people’s living standards,people’s demands on the quality of life are getting higher and higher.And now men’s health is being valued more highly.Erectile dysfunction is one of the most complex disorders in men’s health.It has been established that the no-cgmp pathway plays an important role in male penile erection.The production of NO is mainly catalyzed by three different enzymes.ENOS and iNOS mainly exist in normal tissues,while iNOS are mainly produced after being served by relevant inflammatory mediators.Likewise,numerous studies have shown that testosterone plays an important role in penile erection.In this paper,the relationship among groups of nitric oxide,inducible nitric oxide synthase and testosterone was analyzed by EHS erectile hardness classification methodsAccording to the clinic patients with EHS survey information collection,the four levels of patients according to EHS separately divided into group A and group B,C group and the control group,and then collected venous blood,NO and iNOS,and testosterone value examination,compare different level of EHS,the three indicators have correlation.ResultsIn the EHS level of penile erectile function,the value of NO in the venous blood of erectile function level 1 was statistically significant compared with that of the normal control group.In iNOS,there were statistically significant differences in the content of iNOS between group A and group C and between group A and the control group(P < 0.05).There was no statistically significant difference in serum testosterone in each group.conclusionThere is a correlation between NO and iNOS and penile erectile function,and among the patients with poor erectile function,the content of NO is low and the content of iNOS is high.There was no statistically significant difference in testosterone between patients with organic erectile dysfunction and the normal control group after age and internal secretory disease were excluded.更多还原