【作者】 刘洋；

【导师】 佟胜全；

【作者基本信息】 河北医科大学 ， 内科学， 2017， 硕士

【摘要】 目的:调查唐山地区部分人群高尿酸血症和痛风的患病率,探讨高尿酸血症患病危险因素。方法:对2015年10月至2015年12月于唐山工人医院体检中心进行体检的人群进行研究。签署知情同意书后,对人群进行体格检查及相关生化指标的检测,发放调查表,内容主要涉及:姓名、性别、年龄、联系方式、居住地区(城镇/农村)、文化程度、婚姻状况、是否有以下病史(高血压、糖尿病、血脂异常、高尿酸血症、痛风等)。共收集到有效问卷1198份。统计不同分组人群痛风及高尿酸血症患病率情况并进行比较。高尿酸血症诊断标准:血尿酸水平男性大于420umol/l,女性大于360umol/l。痛风诊断标准采用《2011年欧洲抗风湿联盟痛风和高尿酸血症最新诊治指南》,计数资料以率表示,计数资料比较采用卡方检验。高尿酸血症危险因素分析采用logistic回归分析。结果:1该人群高尿酸血症及痛风总患病率分别为13.27%和2.34%。不同性别的高尿酸血症和痛风患病率相比具有显著差异:男性的高尿酸血症及痛风患病率分别为17.07%和3.74%,显著高于女性高尿酸血症患病率9.26%及痛风患病率0.86%(P<0.05)。2高尿酸血症患病的单因素分析显示居住地区、肥胖/超重、高血压、血脂异常、糖尿病是影响高尿酸血症患病的风险因素,而文化程度、婚姻状况与高尿酸血症患病无统计学意义。3多因素logistic回归分析显示:城镇、肥胖/超重、高血压、血脂异常、糖尿病为高尿酸血症的危险因素结论:1不同性别的高尿酸血症和痛风患病率相比具有显著差异;男性患病比率均高于女性。2城镇、高血压、血脂异常、超重/肥胖、糖尿病是高尿酸血症患病的危险因素。更多还原

【Abstract】 Objective: To investigate prevalences of hyperuricemia and gout in population in Tangshan city,and to explore risk factors of hyperuricemia.Methods: A study was carried out in population who had yearly health examinations at the Health Guidance Center of Tangshan Workers Hospital from October to December 2015.Medical examinations were checked and related biochemical testing with their permission.Collected their name,gender,age,contact information,living area(urban/rural),educational level,marital status,following anamnesis(hypertension,diabetes,dyslipidemia,hyperuricemia,gout,and so on).Ultimately,A total of 1198 questionnaires were valid to make the factors into different groups to compare the prevalences of gout and hyperuricemia.The diagnostic criteria of hyperuricemia: hyperuricemia was defined as serum uric acid>420umol/l in men,and uric acid >360umol/l in women.The diagnostic criteria of gout were diagnosed according to《New guidelines for the diagnosis and treatment of gout and hyperuricemia in European League Against Rheumatism in 2011》.Enumeration data indicated as percentage,the comparison of rate of cases were tested by the chi—square;Date were further analyzed by multivariate logistic regression models to find associated factors of hyperuricemia.Results:1 The prevalence of hyperuricemia and gout in the crowd was 13.2-7% and 2.34%.There was a significant difference of prevalence of hype r-uricemia and gout in people with different genders:Prevalences of hype r-uricemia and gout in men were much higher than those in women(17.07%vs9.26%,3.74%vs0.86% P<0.05).2 The single factor analysis showed that living area,obesity/overweight,hypertension,dyslipidemia,diabetes are risk factors of hyperuricemia,whileeducational level,marital status were not statistically significant.3 Multivariate logistic regression analysis indicated that urban,obesity/overweight,hypertension,dyslipidemia and diabetes are risk factors of hyperuricemia.Conclusion:1 There was a significant difference of prevalence of hyperuricemia and gout in people with different genders:Prevalence of hyperuricemia and gout in men were much higher than those in women.2 Urban,obesity/overweight,hypertension,dyslipidemia and diabetes are risk factors of hyperuricemia.更多还原