【作者】 高颖；

【导师】 卢静鸣；

【作者基本信息】 大连医科大学 ， 儿科学， 2017， 硕士

【摘要】 目的:通过对大连医科大学附属大连市儿童医院因肺炎支原体肺炎住院的儿童的一般情况、肺炎支原体抗体(Mycoplasma pneumoniae antibody Mp-Ab)、C 反应蛋白(Creactive protein CRP)、白细胞及中性粒细胞的分析,探讨肺炎支原体肺炎(Mycoplasma pneumoniae pneumonia MPP)在不同年龄段的患儿血液标本中CRP、白细胞、中性粒细胞的变化,并分析出现此种变化的原因。方法:收集2016年1月-2017年1月大连医科大学附属大连市儿童医院因肺炎支原体肺炎住院的313例儿童的年龄、性别、Mp-Ab、CRP、白细胞计数及中性粒细胞计数情况。Mp-Ab采用血清学胶体金检测法,CRP采用免疫层析法,白细胞及中性粒细胞计数采用电阻抗法血细胞计数检测法。按年龄进行分组,分为三组,<3岁,3~<7岁,≥7~≤14岁。年龄、性别及Mp-Ab阳性为计量资料。CRP、白细胞计数、中性粒细胞计数为计数资料。使用SPSS20.0软件,进行统计学分析。结果:1.肺炎支原体肺炎在不同年龄段CRP、白细胞计数及中性粒细胞计数的变化:<3岁,3~<7岁,≥7~≤14岁患儿的CRP值分别为:24.08±1.29mg/L、13.53±1.21mg/L、8.47±1.09mg/L,差异有统计学意义(P<0.05);三组患儿的白细胞计数分别为:14.6±1.5×10^9/L、9.8±1.4×10^9/L、6.8±0.9×10^9/L差异有统计学意义(P<0.05);三组患儿的中性粒细胞计数分别为:8.6± 1.2×10^9/L、5.8± 1.4× 10^9/L、4.9± 1.1× 10^9/L,差异有统计学意义(P<0.05)。2.肺炎支原体肺炎与年龄的关系:<3岁的患儿例数为80例,比例为25.6%,3~<7岁患儿的例数为113例,比例为36.1%,≥7~≤14岁患儿的例数为120例,比例为38.3%。≥3岁的患儿比例要明显高于<3岁患儿,差异有统计学意义(X2=5.642和8.000,P<0.05);≥7~≤14岁患儿和3~<7岁患儿的比例无统计学意义(X2=0.210,P>0.05)。3.肺炎支原体肺炎患儿的性别差异:男童肺炎支原体肺炎例数为135例,比例为43.1%,女童肺炎支原体肺炎例数为178例,比例为56.9%,女童比例高于男童,差异有统计学意义(X2=5.907,P<0.05)。结论:1.年龄越小的肺炎支原体肺炎患儿,CRP、白细胞计数及中性粒细胞计数升高越明显。2.肺炎支原体肺炎在学龄期及学龄前多见。3.相对于男童,女童易感染肺炎支原体。更多还原

【Abstract】 Objective:According to the Dalian Municipal Children’s Hospital Affiliated to Dalian Medical University for general mycoplasma pneumonia in hospitalized children,mycoplasma pneumonia antibody(Mycoplasma pneumoniae antibody Mp-Ab),C reactive protein(C reactive protein CRP),analysis of white blood cells and neutrophils,investigate mycoplasma pneumonia(Mycoplasma pneumoniae pneumonia MPP)in different age groups children with blood CRP,white blood cells,neutrophils changes,the positive rate of Mp-Ab,and analyzed the reasons of this change.Methods:From January 2016 January-2017 Dalian Medical University Affiliated Children’s Hospital of Dalian city for 313 cases of Mycoplasma pneumoniae pneumonia in children hospitalized in age,gender,Mp-Ab,CRP,white blood cell count and neutrophil count.Mp-Ab by serological detection method using colloidal gold immune chromatography,CRP,white blood cell and neutrophil counts by impedance method in blood cell counting assay.Grouped by age,divided into three groups:<3,3～<7,≥7～<14 years.Age,gender and Mp-Ab positive for measurement data.Crp,white blood cell count,neutrophil count for count data.Using spss20.0 software for statistical analysis.1.The changes of CRP,WBC count and neutrophil count in Mycoplasma pneumoniae pneumonia at different ages:<3,3-7,≥7～≤14 years with CRP:24.08+1.29mg/L,13.53+1.21 mg/L,8.47+1.09 mg/L,the difference was statistically significant(P<0.05);white blood cell count in three groups respectively:14.6±1.5×10^9/L、9.8±1.4×10^9/L、6.8±0.9×10^9/L,the difference was statistically significant(P<0.05);the three groups of children with neutrophil counts were 8.6±1.2±10^9/L、5.8±1.4×10^9/L、4.9±1.1×10^9/L,the difference was statistically significant(P<0.05).2.The relationship between Mycoplasma pneumoniae pneumonia and age:The number of cases of children<3 years oldwas 80 cases,the ratiowas 25.6%,the number of cases of 3～7 years old children was 113 cases,the ratio was 36.1%,the number of cases of ≥7～≤14 years old children was 120 cases,the ratio was 38.3%.≥3 years old were significantly higher than the proportion of less than 3 year old children was statistically significant the difference(X2 = 5.642 and 8,P<0.05);Thexe no statistical significance between 3～<7 years old children and ≥7～≤14 years old children,(X2=0.210,P>0.05).3.The relationship between gender and children with Mycoplasma pneumoniae pneumonia:The number of Mycoplasma pneumoniae pneumonia in boys was 135,the ratio was 43.1%,the number of mycoplasma pneumonia in girls was 178,the ratio was 56.9%,the proportion of girls was higher than boys,the difference was statistically significant(X2 = 5.907,P<0.05).Conclusion:1.The younger the children with Mycoplasma pneumoniae pneumonia,the higher the CRP and WBC count and neutrophil count.2.Mycoplasma pneumoniae pneumonia is common in school age and preschool age3.Compared with boys,girls are susceptible to Mycoplasma pneumoniae.更多还原