【作者】 陈乐；

【导师】 孙晓江；

【作者基本信息】 上海交通大学 ， 神经病学， 2015， 硕士

【摘要】 目的:脑梗死是一种高风险、高致残、高死亡的疾病,给社会和家庭带来了沉重的负担,因此脑梗死的预防和治疗意义重大。本研究评价注射用丹参多酚酸治疗脑梗死改善神经功能缺损症状和提高生活能力的效果,同时观察药物的安全性。方法:根据入组标准收治急性脑梗死患者64例,随机分为实验组和对照组各32例。实验组予以基础治疗加注射用丹参多酚酸治疗,对照组只予以基础治疗,疗程为14天。患者在入院第0天和第15天接受了神经功能缺损(Nominal Institute of Health stroke scale,NIHSS)和日常生活活动能力(Activity of Daily Living Scale,ADL)评分,并进行相关检查。结果:实验组和对照组患者治疗前的NIHSS评分及ADL评分无统计学差异;治疗后两组的NIHSS评分均有降低,实验组(7.31±3.63)降低显著于对照组(9.56±3.65),差异有统计学意义(P<0.05);治疗后两组的ADL评分均有增加,实验组(57.97±5.66)增加显著于对照组(50.31±6.83),差异有统计学意义(P〈0.001);根据治疗前后NIHSS评分的变化评定临床疗效,实验组为68.75%,对照组为53.13%,差异具有统计学意义(P<0.05);实验组和对照组不良事件的发生率分别为6.25%、3.12%,组间比较p>0.05,差异无统计学意义。结论:注射用丹参多酚酸能明显改善脑梗死患者神经功能缺损症状,提高患者日常生活能力,且安全性较好,值得临床推广应用。更多还原

【Abstract】 Objective:Cerebral infarction is a disease with the characteristics of high-risk, high disability and high mortality, which causes heavy burdens on society and family. Thus,it is very important to investigate the prevention and treatment of cerebral infarction.The objectives of this study is to study the effect of salvianolic acids used in clinical on treatment of cerebral infarction, improvement of nerve function defect symptoms as well as life ability,and to survey the safety of clinical application.Methods:64 acute cerebral infarction patients were involved in this study. They were randomly assigned into two groups(experiment group and control group) with 32 patients in each group. The patients in experimental group received the basic treatment and the treatment of salvianolic acids, while the patients in control groups only received the basic treatment. The courses of treatment were 14 days. The patients in both groups received the evaluation of nerve function defect based on the criteria of Nominal Institute of Health Stroke Scale(NIHSS) and activity of daily living according to the standard of Activity of Daily Living Scale(ADL) at the zero and fifteen days. Meanwhile, the relevant inspections were made on the patients.Results:The results show that there is no statistically significant difference of the scores of NIHSS and ADL before the treatment for the patients in both groups. The scores of NIHSS for the patients in both groups decreased after treatment. And the decrease degree(7.31±3.63) for the experimental group was more pronounced than that for the control groups(9.56±3.65). Also, the difference presents the statistically significant(P<0.05). In addition, the scores of ADL for the patients in both groups increased after treatment. And the increase extent for the experimental group(57.97±5.66) was more obvious than that for the control group(50.31±6.83). And the difference shows the statistically significant(P<0.001).The clinical effects of salvianolic can be evaluated according to the change of NIHSS scores before and after treatment. The effective rates for experimental group and control group were 68.75% and 53.13%, respectively. This difference exhibits the statistically significant(p<0.05).The incidences of adverse effect were 6.25% and 3.12% for experimental group and control group, respectively.Conclusion: It is concluded that salvianolic acids used in clinical can significantly improve the nerve function defect symptoms of patients and increase the activity of daily living.Due to its good safety, it is worth to be popularized.更多还原