【作者】 王烨；

【导师】 张宝荣；

【作者基本信息】 浙江大学 ， 临床医学七年制（专业学位）， 2016， 硕士

【摘要】 目的：探究帕金森病(PD)患者体重变化的水平以及影响因素方法：本研究以浙江大学医学院附属第二医院病例为基础进行1：1配对对照研究。收集2014年1月1日到2016年1月1日于浙江大学医学院附属第二医院神经内科门诊及住院就诊的原发性帕金森病患者。初诊患者由专职神经内科教授进行全面询问、体格检查及神经系统检查,最后确定诊断。对照为同时期定期体检人群。与病例在性别、民族、年龄(±2岁)方面相匹配。对照无PD及其他锥体外系疾病。病例对照共计227对,包括126对男性和101对女性,随访间隔时间为1年。利用SPSS 20.0分析病例组和对照组的体重、BMI在a=0.05水平上是否存在显著性差异,接着研究帕金森病例组体重变化的相关因素。结果：PD病例组较对照组存在更为普遍的体重下降现象(p<0.05),两组中体重减轻者的性别分布并无显著性差异。纳入时两组的平均体重差异并不显著,而BMI值存在显著性差异(p<0.05),随访结束时病例组的平均体重下降值显著大于正常对照组(p<0.05)。病例组中体重下降的患者和体重未下降的患者年龄、起病年龄差异不明显,病程长短存在显著性差异。结论：帕金森病患者体重下降的风险增高,主要体现在平均体重下降。该风险与患者性别、年龄、起病年龄无关,与病程长短、服药、嗅觉减退、咀嚼困难、心情低落等有关。更多还原

【Abstract】 Objective:To compare weight loss in patients with Parkinson’s disease and matched control subjects and investigate the influence factors.Methods:This study was an 1:1 case control study based on the Second Affiliated Hospital of Zhejiang University. Outpatients and resident patients with idiopathic Parkinson’s disease were recruited from the Department of Neurology in the Second Affiliated Hospital of Zhejiang University between January 1st 2014 and January 1st 2016. The preliminary diagnosis was made by professor of neurology after enough inquiry and physical examination. Patients of the control group were matched on the respect of gender, nationality and age. There were 126 pairs of men and 101 pairs of women. Duration of follow-up was one year. The data obtained were processed with SPSS 20.0.Results:Patients with Parkinson’s disease were more likely to report weight loss than the matched control subjects(p<0.05). No significant difference of gender between two groups’ number of people with weight loss. There are statistically differences in the aspects of BMI when recruited and PD duration.Conclusion:Patients with Parkinson’s disease appear to be at greater risk of weight loss than a matched population. Possible determinants of weight loss in PD patients include duration of PD, hyposmia, difficulty chewing, dysphagia, depression, nausea, and anorexia as the side effects of medication, and increased energy requirements due to muscular rigidity and involuntary movements.更多还原