【作者】 王璐；

【导师】 赵龙凤；

【作者基本信息】 山西医科大学 ， 内科学（专业学位）， 2016， 硕士

【摘要】 目的:探讨幽门螺杆菌(Helicobacter pylori,Hp)现症感染与非酒精性脂肪性肝病(Nonalcoholic fatty liver disease,NAFLD)及代谢综合征(metabolic syndrome,MS)组分间的相关性,为预防和控制NAFLD及MS提供科学依据。方法:采用横断面调查研究方法,分析2015年4月至2015年7月于山西省人民医院体检中心进行健康体检者中体检数据完整、进行13C-尿素呼气试验检测Hp及腹部超声检查的受试者3447人。依据13C-尿素呼气试验检测结果分为Hp阴性组1742例,Hp阳性组1705例。应用非条件Logistic回归分析Hp感染状态与NAFLD及MS相关组分间的关系。结果:1、在3447例体检者中,检出NAFLD患者1354例(39.3%),检出Hp阳性者1705例(49.5%);2、男性体检者中Hp阳性者较Hp阴性者血尿酸(uric acid,UA)高,而高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)低;3、女性体检者中Hp阳性者较Hp阴性者体质量指数(body mass index,BMI)高,但这一相关性存在于BMI正常水平情况下;4、在这项研究中,NAFLD患病率、甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、空腹血糖(fasting plasma glucose,FPG)水平在不同性别中差异均无显著性;5、Hp感染与NAFLD关联无显著性。结论:幽门螺杆菌感染可能对UA和HDL-C水平有影响,而对NAFLD患病率、BMI、TG、TC、LDL-C及FPG水平无明显影响。更多还原

【Abstract】 Objective:To investigate the relationship between helicobacter pylori(Hp) infection and nonalcoholic fatty liver disease(NAFLD) and the elements of metabolic syndrome(MS),providing a scientific basis for the prevention and control of NAFLD and MS. Methods:Analysis datas from 3447 subjects who receive 13 C urea breath test to detect Hp and abdominal ultrasound examination from April to July 2015 in the physical examination center of Shanxi Province people’s hospital,using cross-sectional analysis methods.The subjects are divided into Hp negative group and and Hp positive group on the basis of 13 C urea breath test results,having 1742 and 1705 cases respectively. Unconditioned Logistic regression was used to analysis the relationship between Hp infection status and NAFLD and the components of metabolic syndrome.Results In male subjects, a higher uric acid(UA) level and a lower high-density lipoprotein cholesterol(HDL-C) level is observed in Hp positive group than Hp negatie group, In the female subjects, though a higher body mass index(BMI) level is observed in the Hp positive group,there is no medical value since this relationship is within a normal BMI level.In the present study,there is no significant difference in the prevalence of NAFLD, triglycerides(TG), total cholesterol(TC), low-density lipoprotein cholesterol(LDL- C) and fasting plasma glucose(FPG) level in both gender. Results:1.Of all the 3447 cases of physical examination subjects,check out 1354 cases of NAFLD patients(39.3%),1705 cases of Hp positive subjects(49.5%);2.In the male subjects,a higher uric acid(UA) level and a lower high-density lipoprotein cholesterol(HDL-C) level is observed in Hp positive group than Hp negatie group;3.In the female subjects,a higher body mass index(BMI) level is observed in the Hp positive group,however,this relationship is within a normal BMI level;4.In the present study,there is no significant difference in the prevalence of NAFLD, triglycerides(TG), total cholesterol(TC), low-density lipoprotein cholesterol(LDL- C) and fasting plasma glucose(FPG) level in both gender;5.There is no significant correlation between Hp infection and NAFLD. Conclusion:Helicobacter pylori infection may have an impact on UA and HDL- C level,but for NAFLD prevalence, BMI, TG, TC, LDL- C and FPG level,there is no significant correlation.更多还原