【作者】 刘伟；

【导师】 刘兵元；

【作者基本信息】 石河子大学 ， 临床医学， 2015， 硕士

【摘要】 目的:1、探讨首次经皮肝动脉化疗栓塞术(TACE)对原发性肝癌患者肝、肾功能的近期影响。2、评价TACE对肝功能Child A级和Child B级患者肝肾功能的影响是否有差异。3、比较微导管超选择化疗栓塞与常规插管化疗栓塞对患者肝肾功能的影响是否存在差异。方法:对本院救治的160例原发性肝癌患者进行TACE治疗,分析术前、术后一周和术后一月的肝功能情况(ALT、AST、ALP、ALB、γ-GT、Tbil、Dbil)及肾功能(Bun、Cr)的变化规律。结果:原发性肝癌患者首次TACE后一周肝功能呈一过性损伤,Child A级患者术后一月即可恢复;Child B级患者术后一月较术后一周有显著恢复,但不能恢复至术前水平。对于肾功能来讲,无论Child A级和Child B级患者TACE术后一周肾功能呈一过性损害表现,术后一个月较术后一周明显好转,且能恢复到术前水平。微导管的使用虽然能造成肝功能的损害,但是对肝功能的损害明显优于常规插管。结论:原发性肝癌患者首次TACE对肝功能的损害是一过性、暂时性的,经保肝、补液等综合对症治疗后,可恢复到术前水平。对于肾功能来讲,无论Child A级和Child B级患者TACE术后一周肾功能呈一过性损害表现,术后一个月较术后一周明显好转,且能恢复到术前水平。微导管的使用能从更大程度上减轻TACE对患者的肝功能的影响,从而保护患者的肝功能,使患者的肝功能在更短的时间内得到恢复。更多还原

【Abstract】 Object 1.Discuss first percutaneous hepatic artery chemoembolization(conventional) of the liver and renal function in patients with primary liver cancer recently 2.Evaluation of liver function with conventional Child class A and Child class B, the influence of liver and kidney function in patients with whether there is A difference.3. Compared with conventional intubation micro catheter super chemotherapy embolism and chemotherapy embolism effects on kidney function in patients with whether there is a difference.Methods To the treatment of 160 cases of primary liver cancer patients with conventional treatment,analysis of preoperative and postoperative week in January and postoperative liver function(ALT, AST,ALP, ALB,γ-GT, Tbil, Dbil) and the changing rule of the renal function(Bun, Cr).Results Primary liver cancer patients for the first time after A week with conventional liver function is transient damage, A grade Child patients postoperative resumed in January; January from postoperative week postoperatively in patients with Child class B a significant recovery, but can’t return to preoperative levels. For renal function in any Child grade A or grade B, all follow-up points before and after comparison with conventional had no significant difference. Micro catheter use can cause liver damage, but the damage to the liver function is superior to conventional intubation.Conclusions Primary liver cancer patients for the first time the damage to the liver function is transient,with conventional temporary, protect liver, rehydration after comprehensive symptomatic treatment, can be recovered to preoperative levels. The damage to the kidney function has no obvious statistical significance.The use of micro catheter can reduce the conventional TACE from more influence on patients with liver function, thus protecting the patient’s liver function, make the patient’s liver in a shorter period of time to recover.更多还原