【作者】 王艳；

【导师】 孙晓风；

【作者基本信息】 新疆医科大学 ， 内科学（专业学位）， 2015， 硕士

【摘要】 目的：探讨新疆地区布氏杆菌病的流行情况、临床特征、相关检查及治疗结果。方法：分析我院2012年7月——2014年4月收治的117例布氏杆菌病患者的临床特征及治疗效果。结果：收集的117例布氏杆菌病患者平均年龄为40.67+12.25岁,其中79.49%为男性,男女比例为3.86：1,本地区布氏杆菌病以4—9月份高发,发病地区比较分散,但主要以昌吉回族自治州(26例)、塔城地区(22例)为主,发病人群仍以农牧民为主,占到56.41%,与畜牧相关的个体经营者也占到11.11%,主要临床表现除发热(80.34%)、多汗(39.32%)、乏力(50.43%)、关节痛(24.79%)等一般症状外,部分患者还出现肝肿大(14.53%)、脾肿大(36.75%)、淋巴结肿大(35.04%),实验室检查中患者出现红细胞沉降率(79.49%)、降钙素原(77.78%)C-反应蛋白(55.56%)升高,生化检查中ALT(46.15%)、AST(43.60%)升高及γ-谷氨酰转肽酶(45.3%)升高,治疗以多西环素联合利福平为主,或联合氨基糖苷类或喹诺酮类中的一种,一般疗程为6周,治疗好转率为97.44%。结论：布氏杆菌为新疆地区发病比例较高的传染病,要加强畜牧相关人员的防疫,当地有关部门应普及布病防护知识,布氏杆菌病的临床特点也在不断发生变化,临床医生应关注其并发症及合并症,并进行规范的抗菌治疗。更多还原

【Abstract】 Objective:To investigate the prevalence,clinical characteristics, laboratory findings and treatment outcome of brucellosis in Xinjiang.Method:Clinical features and therapeutic effect were analyzed in117 patients with brucellosis admitted to our hospital from July.2012 to April.2014.Results:Collected 117 cases of brucellosis in patients with a mean age of 40.67±12.25 years,of which 79.49% were male to female ratio was 3.86:1, the region brucellosis with 4-9 month high, the incidence of scattered areas, but the main Changji Hui Autonomous Prefecture(26 cases), Tacheng(22 cases) mainly farmers and herdsmen,accounting for 56.41%,and the livestock-related accounted for 11.11%, the main clinical manifestations fever (80.34%),sweating (39.32%), fatigue (50.43%), arthralgia (24.79%) and other general symptoms, some patients hepatomegaly (14.53%), splenomegaly (36.75%), lymphadenopathy(35.04%), laboratory examination of patients erythrocyte sedimentation rate (79.49%), Procalcitonin (77.78%), C-reactive protein (55.56%) increased biochemical tests in ALT(46.15%), AST (43.60%) and elevated y-GT(45.3%) increased, treatment with dosycycline combined with rifampin-based, or in combination with aminoglycosides or quinolones one, the general course of six weeks, the treatment of 97.44%improvement.Conclusions:Brucellosis is a more frequent infectious disease in Xinjiang, so it is emphasized to strengthen the immunization of livestock related personnel, local authorities should spread brucellosis protection knowledge, Clinical characteristics of brucellosis are constantly changing, Clinicians should focus on its complications and comorbidities, and standard antimicrobial therapy.更多还原