【作者】 李波；

【导师】 王忆铭； 吕小兵；

【作者基本信息】 大连理工大学 ， 精细化工， 2015， 硕士

【摘要】 硅胶具有化学惰性、生物相容性、热稳定性及易硅烷化衍生等优点,在生物学、电子学、工程学及光学等领域得到广泛应用。但由于其溶解性差、在溶剂中分散度低,其性能与应用也受到了很大的限制。以CO2作为碳源合成的可降解性聚碳酸酯是环境友好型高分子,然而其较低的热稳定性、力学性能限制了它的广泛应用。本课题利用绿色的“表面引发不朽聚合”方法,在催化剂的作用下,由硅胶表面活性基团(-OH)引发CO2和环氧化合物交替共聚反应,原位制备了聚碳酸酯/硅胶纳米复合材料。制备的聚碳酸酯/硅胶纳米复合材料不仅提高了硅胶在有机溶剂中的溶解性和分散性,同时也改善了聚碳酸酯的耐热性和力学性能,为硅胶和聚碳酸酯的改性和推广应用提供了一条可行的方法。表面抗蛋白非特异性吸附、抗细胞/细菌吸附和生物膜的形成是生物医药和分析仪器应用和发展的关键。金由于本身具有良好的导电性、抗氧化性和易于表面修饰等优点而成为纳米修饰的基体,制备成为生物微电子器件,被广泛应用于生物医药和生物分析设备。然而,由于其表面在生物环境中易于吸附蛋白和细胞而影响仪器的灵敏性。因而,修饰金表面增强其抗蛋白非特异性吸附性是十分有必要的。在本文中,设计合成了一种带有聚乙二醇(PEG)链的环氧烷烃单体,利用“表面引发不朽聚合”方法,由金表面自组装带有的羟基(-OH)引发CO2和环氧化合物单体(ME3MO)交替共聚反应合成侧链带有PEG链的聚碳酸酯聚合物刷,经过表征和测试证实了接枝有聚合物刷的金具有良好的抗蛋白非特异吸附性。该方法合成的聚合物刷可生物降解,为表面抗污领域提供了一种环保的方法。更多还原

【Abstract】 SiO2 has many advantages, such as chemically inert, thermal stability and easily silylated derivatives. It is widely used in the field of biology, electronics, optical engineering and etc. However, the poor solubility and low dispersion in solvents limit its application. Using CO2 as carbon source to synthesize the degradable polycarbonates is an environmentally friendly polymerization process. However, the low mechanical properties of CO2-based polycarbonates significantly restrict their wide application. In this thesis, "surface initiated immortal polymerization" was used to the grafting of CO2/epoxide alternating copolymer on SiO2 surface from the active group (-OH) on SiO2. The resultant polycarbonate/silica nanometer materials improve not only the solubility of silica in organic solvents and dispersion, but also the heat resistance and mechanical properties of polycarbonates. The present study provides a feasible method for the modification of silica gel, and thus benefitting the application of CO2-based polycarbonates.Surface resistance to nonspecific protein adsorption, cell /bacterial adhesion, and biofilm formation is critical for the development and performance of biomedical and analytical devices. Due to its electrical conductivity, oxidation resistance and easy surface modification, gold is widely used as matrix nano-modification for the preparation of biological microelectronic devices, which was widely used in biomedical and biological analysis equipment. Nevertheless, due to the surface in a biological environment is easy to absorb protein and cells, significantly influencing the instrument sensitivity. Therefore, the modification of gold surface for enhancing the anti-nonspecific adsorption of proteins is very necessary. In this thesis, a epoxy alkane monomer with a polyethylene glycol (PEG) chain was synthesized, and further applied to the synthesis of polycarbonate brush with side PEG chains via the "surface initiated immortal polymerization", in which the polymerization was initiated by gold surface hydroxyl (-OH). It was found that the gold grafted with polymer brushes had good anti-nonspecific adsorption of proteins. The polymer brush synthesized by "surface initiated immortal polymerization" is biodegradable. This study provides an environmental friendly method for surface antifouling areas.更多还原