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右半结肠癌根治术后吻合口出血的原因分析及治疗

The Cause and Treatment Method of Anastomotic Bleeding after Radical Resection of Right Colon Cancer

【作者】 李凯

【导师】 刘铜军;

【作者基本信息】 吉林大学 , 外科学(专业学位), 2015, 硕士

【摘要】 目的:分析右半结肠癌根治术后吻合口出血的原因,探讨术中预防出血的方法,选择术后最佳治疗方案。方法:收集我院2011年1月至2014年6月间行右半结肠癌根治术的患者195例,并进行回顾性分析,其中发现吻合口出血7例(术中3例,术后4例);分析吻合口出血的原因是否与患者性别、年龄、手术方式、梗阻因素、病理分期有关。同时总结术中预防吻合口出血的具体方法和注意事项,提出吻合口出血的临床诊断标准和最佳的治疗方案。结果:1、195例右半结肠癌根治术合并吻合口出血发生率为3.6%(7/195),其中术中发生率1.5%(3/195)术后发生率2.1%(4/195),右半结肠癌根治术合并吻合口出血的患者中男性与女性的发病率分别为4.46%(5/112)和2.41%(2/83),P>0.05(χ2=0.581),年龄≥55岁与<55岁发生率分别为4.05%(6/148)和2.13%(1/47),P>0.05(χ2=0.382),开腹手术与腹腔镜手术发生率分别为2.78%(4/144)和5.88%(3/51),P>0.05(χ2=1.049),有肠梗阻与无肠梗阻发生率分别为4.35%(1/23)和3.49%(6/172),P>0.05(χ2=0.043),病理分期I期,II期,III期,IV期的发生率分别为0%(0/10)、5.21%(5/96)、2.35%(2/85)、0%(0/4),P>0.05(χ2=1.624)。2、3例术中即发现吻合口活动性出血,缝合出血点后治愈,无术后继续出血,无其他并发症,顺利出院,平均住院9.2天;4例于术后3-6小时出现血便,并有不同程度的失血性休克表现,2例给予常规剖腹探查,行吻合口切除再吻合术,2例给予内镜下止血,行钛夹夹闭出血点,4例止血均获得一次性成功,无继续出血及其他术后并发症,顺利出院,手术止血者平均住院13.5天,内镜止血者平均住院10.5天。结论:1、右半结肠癌术后吻合口出血的发生在性别、年龄、手术方式、有无梗阻、病理分期上的差异无明显统计学意义。2、右半结肠癌根治术后吻合口出血在治疗上首选急诊内镜下止血,其次选择再次急诊手术治疗,不宜选择保守治疗,否则会危及生命。

【Abstract】 Objective:To observe the cause of anastomotic bleeding in radical resection of rightcolon cancer,explore its prevention methods during the operation and best wayto treat after operation.Method:Statistics195cases of radical resection of right colon cancer fromJanuary2011to June2014in our hospital,7cases of anastomotic bleeding(3cases during operation,4cases after operation). Analysis the relationship withthe incidence of anastomotic bleeding and the factors which include thegender,the age,the operation method,the obstruction factors,the pathologicalstage. Summarize the intraoperative considerations to prevent anastomoticbleeding, At the same time we put forward the clinical diagnostic criteria ofanastomotic bleeding and the best treatment method.Results:1、The incidence of anastomotic bleeding in radical resection of rightcolon cancer is3.6%(7/195)in195cases,in which1.5%(3/195)duringoperation,2.1%(4/195)after operation。The incidence of men and women is4.46%(5/112)and2.41%(2/83),P>0.05(χ2=0.581).The incidence of≥55 and<55is4.05%(6/148)and2.13%(1/47),P>0.05(χ2=0.382). Theincidence of open and laparoscopic surgery is2.78%(4/144)and5.88%(3/51),P>0.05(χ2=1.049). The incidence of with or without obstruction factors is4.35%(1/23)and3.49%(6/172),P>0.05(χ2=0.043). The incidence ofpathological stage I,II,III,IV is0%(0/10)、5.21%(5/96)、2.35%(2/85)、0%(0/4),P>0.05(χ2=1.624).2、3cases were found active bleeding during operation and cured throughsuture the hemorrhagic spot.4cases were found hematochezia in3-6hoursafter operation and have different degrees of uncontrolled hemorrhagic shock,2cases cured through surgery with anastomotic resection,2cases cured throughendoscopic treatment with titanium clip.All7cases cured and there is nocontinuous bleeding until hospital discharge.Conclusions:1、The difference between the gender,the age,the operation method,theobstruction factors,and the pathological stage in anastomotic bleeding afterradical resection of right colon cancer has no statistical significance.2、In the treatment, endoscopic treatment is the first choice and next issurgical treatment, we should not choose the conservative treatment because itcan be life-threatening.

  • 【网络出版投稿人】 吉林大学
  • 【网络出版年期】2015年 09期
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