【作者】 赵丽丽；

【导师】 李爱丽；

【作者基本信息】 吉林大学 ， 神经病学（专业学位）， 2015， 硕士

【摘要】 背景：脑梗塞是目前严重危害老年人健康的疾病之一,具有发病率高、致残率高、病死率高、复发率高及并发症多的“四高一多”的特点,而且最近几年脑梗塞发病有明显年轻化趋势。目前脑梗塞已严重威胁人类健康,对人类健康及家庭社会经济造成很大负担，因此做好脑梗塞的诊治有着极其重要的意义。神经营养因子作用于神经系统，影响神经元和胶质细胞生长、分化及存活，碱性成纤维细胞生长因子(basicfibroblast growth factor，bFGF)是其中的一种神经营养因子。近年来有关bFGF在脑梗塞方面的研究引起了众多学者的关注。目的：本研究通过检测急性期脑梗塞患者血清bFGF含量，探讨bFGF与脑梗塞的关系及临床意义。方法：研究对象为脑梗塞组84例急性期脑梗塞患者和对照组30例健康体检者。脑梗塞组根据采血时间不同将其分为发病1d、7d、14d组。同时按郭玉璞病灶大小分型法,将脑梗塞组分为小梗塞组(最大直径＜1.5cm)、中梗塞组(1.5cm≤最大直径＜5cm)及大梗塞组(最大直径≥5cm)。应用酶联免疫吸附（Enzyme-Linked ImmunoSorbentAssay，ELISA）法检测84例脑梗塞患者发病1d、7d、14d血清bFGF含量，用同样方法检测对照组30例健康体检者血清bFGF含量。应用spss19.0统计软件进行统计学处理，计量资料用均值±标准差（x±s）表示。结果：1.脑梗塞组患者发病第1d、7d、14d血清bFGF含量（ng/L）分别为17.53±6.98、12.58±5.98、8.14±4.24，对照组为4.81±2.29，经统计学处理，结果显示：脑梗塞发病第1d、7d、14d血清bFGF含量均明显高于对照组（P＜0.01），而且脑梗塞发病第1d、7d、14d血清bFGF含量之间也均有显著性差异(P＜0.01)2.大梗塞组患者发病第1d、7d、14d血清bFGF含量（ng/L）分别为26.94±3.68、18.89±5.48、12.91±4.31，中梗塞组患者发病第1d、7d、14d血清bFGF含量（ng/L）分别为18.54±5.32、13.28±4.65、8.65±3.16，小梗塞组患者发病第1d、7d、14d血清bFGF含量（ng/L）分别为12.93±4.47、9.07±3.75、5.80±2.94。经统计学处理，三组患者血清bFGF含量在组间各时间点均有显著性差异(P＜0.01)，而且每组脑梗塞患者，其组内不同时点间血清bFGF含量均有显著差异(P＜0.01)。结论：1.急性期脑梗塞患者血清bFGF含量与梗塞病灶大小呈正相关。2.急性期脑梗塞患者血清bFGF含量与脑梗塞发病时间长短呈负相关。3.脑梗塞急性期检测血清bFGF含量对评估病情程度可能具有重要临床意义。更多还原

【Abstract】 Backgroud:The health of senior are threated by the cerebral infarctionseriously. It has high incidence rate、disability rate、mortality rate、recurrence rate and many complications,the number of young patient withcerebral infarction is increasing. Cerebral infarction has been severelythreatening human health, affecting human health and social economy. Thediagnosis and treatment of cerebral infarction is extremely important.Neurotrophic factors can promote the growth, differentiation and survivalof neurons and glial cells, bFGF is one of the many neurotrophic factors. Inrecent years,more and more people pay attention to study of bFGF.Objective:To assess the clinical significance of serum basic fibroblastgrowth factor (bFGF) in cerebral infarction by measuring the change of itslevel in the patients with cerebral infarction．Methods：The subjects are consisted of the experimental group of84patients with acute cerebral infarction and the control group of30healthy individuals. Patients’ blood samples of the experimental group iscollected within24hours,7days and14days after cerebral infarction. Thepatients with acute cerebral infarction are divided into3groups accordingto the size of the infarction. Serum levels of bFGF of84cases of acutecerebral infarction were measured by ELISA.30healthy subjects set as control group. SPSS19.0statistical software was used for statisticalprocessing.Results:(1)Serum levels of bFGF were17.53±6.98、12.58±5.98、8.14±4.24inpatients with acute cerebral infarction after the onset of the1d,7d,14d,serum level of bFGF is4.81±2.29in healthy subjects. Serum level ofbFGF were significantly higher (P＜0.01) in patients with acute cerebralinfarction after the onset of the1d,7d,14d.Serum levels of bFGF weresignificant differences in patient groups with acute cerebral infarction afterthe onset of the1d,7d,14d(p＜0.01).(2)Serum levels of bFGF were26.94±3.68、18.89±5.48、12.91±4.31inpatients with acute cerebral infarction which the largest diameter ofnecrosis is more than5cm after the onset of the1d,7d,14d.Serum levels ofbFGF were18.54±5.32、13.28±4.65、8.65±3.16in patients with acutecerebral infarction which the largest diameter of necrosis is between1.5cmand5cm after the onset of the1d,7d,14d.Serum levels of bFGF were18.54±5.32、13.28±4.65、8.65±3.16in patients with acute cerebralinfarction which the largest diameter of necrosis is less than1.5cm after theonset of the1d,7d,14d. Serum levels of bFGF were significant differencesin differrent patient groups with acute cerebral infarction after the onset ofthe1d,7d,14d(p＜0.01). Conclusion：1.Serum level of bFGF and the size of lesion are closely related inpatients with acute cerebral infarction.2.As time goes on,serum level of bFGF decreases gradually in patientswith cerebral infarction.3.Measuring the serum level of bFGF has a very important clinicsignificance in acute cerebral infarction.更多还原