【作者】 刘玉红；

【导师】 王迎军；

【作者基本信息】 华南理工大学 ， 材料学， 2013， 硕士

【摘要】 纳米纤维素（nanocellulose，简称NCC）是一种天然高分子材料，来源丰富，且具有亲水性、生物可降解性、生物相容性及力学性能好等优点，在生物医学上具有良好的应用。本文以NCC为模板，通过在快速矿化液（Fast calcification solution，简称FCS）中矿化的方法在NCC表面沉积羟基磷灰石（hdroxyapatite，简称HAP），并对纳米纤维素的矿化机理进行研究。本文分别以棉短绒、微晶纤维素为原料，采用64%的硫酸酸解，在一定的温度下催化水解制备出了在水中稳定分散的NCC悬浮液，并研究了不同原料对NCC尺寸及结构的影响。采用FTIR、SEM、XRD对NCC的结构进行了分析，结果表明纳米纤维素为短棒状；以棉短绒为原料所制备得到的NCC的直径约为10-20nm，长度约为200nm左右，长径比约为10-20；以微晶纤维素为原料所制备得到的NCC的直径约为20-50nm，长度约为100nm左右，长径比约为2-5。以微晶纤维素为原料制备得到的纳米纤维素粒度较小。采用预钙化的方法增强NCC的表面活性，改善NCC基体合成磷灰石的能力。结果表明采用预钙化和快速矿化液矿化可以在NCC表面沉积一层HAP成分，从而形成一种表面为HAP的纳米复合材料，沉积层致密；材料表面的HAP沉积层厚度随矿化时间的延长而增加。沉积成分的结晶度低、颗粒小。采用硅烷偶联剂KH550对NCC进行氨基化改性，将氨基接枝在NCC上。结果表明氨基化改性使NCC基体很容易与溶液中的PO43-结合，从而使NCC表面HAP的沉积过程发生改变。更多还原

【Abstract】 Nanocellulose (NCC) is a kind of natural polymer materials,hydrophilic, biodegradability,biocompatibility and mechanical performance is good, so it has a good application inbiomedicine. Based on the NCC as a template, use chemical mineralization deposition methodprepare the HAP materials in Fast calcification solution(FCS). Andthe mineralizationmechanism of nanocellulose is studied.Based oncotton linter and microcrystalline cellulose as raw material, use the64%sulfuricacid solution, at a certain temperature catalytic hydrolysis preparation of a stable dispersion ofNCC suspension.And study the effect ofdifferent material on morphology and structure ofNCC. by using FTIR, SEM and XRD analyses the structure of the NCC, the results showedthat NCC has short rod structure;and the diameter of NCC prepared by cotton linter is about10-20nm, length is about200nm, length to diameter ratio is about10-20; and the diameter ofNCC prepared by microcrystalline cellulose is about20-50nm, length is about100nm, lengthto diameter ratio is about2-5.Adopt the method of preliminary calcify enhance surface activity of NCC, improve theability of NCC substrate induced apatite formation. The results show that the HAP/NCCcomposite was fabricated through pre-calcification and fast calcificationsolutionmineralization. A layer of HAP composition deposits at the NCC surface, and thesediment density; the HAP sedimentary thickness increases with longer duration ofmineralization. The sedimentary composition has a low crystallinity, small particles.The surface of NCC is modified by silane coupling agent KH550,the amino grafted onNCC.The results show that the NCC can easy combine with PO43-after amino modification,,so that the deposition process of HAP on NCC surface change.更多还原