【作者】 陈曦；

【导师】 李浩莹；

【作者基本信息】 苏州大学 ， 机械电子工程， 2013， 硕士

【摘要】 肺部给药系统指将药物通过特殊给药装置以非侵入方式传递到肺部，产生局部或全身治疗作用。药物形态和吸入装置的选择是影响肺部沉积率的重要因素，通常认为药物粒径在1~5μm时，有效沉积率最高。本文基于振动网孔技术和夹心式压电换能器技术设计出一种创新型压电驱动的振动网孔式雾化器，基于这种微孔板振动所设计出的雾化器能够产生粒径更小、粒度分布更窄的雾滴，极适用于微纳粉体制造仪––喷雾干燥机的喷头，此外在医用雾化器、喷墨打印等领域也有广阔的应用前景。本文主要开展了如下的工作：（1）依据压电理论和换能器设计的研究方法，选择纵向振动的夹心式换能器作为压电微喷的驱动单元，并对其结构进行理论建模计算。（2）采用ANSYS软件进行压电耦合的仿真，主要应用动力学分析方法分析得出了振动网孔式喷头的谐振频率和其瞬态响应情况。并按照有限元的分析方法同时仿真分析了超声振子及振动网孔雾化器的节面位置，为喷头装夹位置提供了依据。（3）介绍了微喷系统的结构组成、工作原理，分析了微孔板振动过程中气泡的影响及产生原因。（4）利用电子天平与摄像机采集了微喷头工作中流率的变化，解释了流率变化的原因。并采用冷冻干燥和扫描电镜方法对微喷头产生的雾滴进行固化后表征，粒径的大致分布在5~20μm之间，能满足微纳制造的要求。更多还原

【Abstract】 Pulmonary drug delivery means that the drug is delivered to the lungs in anon-intrusive way with special devices, and brings out local or systemic treatment effect.The main factors determining the deposition rate in the lungs are the drug formulations andinhalers. In general, drug particle size in1~5μm is regarded with higher deposition rate.The new type vibrating mesh nebulizers are constructed in use of the technology ofsandwich piezoelectric ultrasonic transducer and vibrating mesh plate technology, and cangenerate tiny droplets with narrow size distribution. Therefore, the new type vibratingmesh nebulizers is suitable for submicro-&nano-powder manufacturing instrument–thenano spray dryer. In addition, this novel technology have a great potential application inmanufacturing the new type of medical nebulizers, ink-jet printing and other fields. Themain results in this study is summarized as follows:(1) The mode of vibration of the ultrasound transducer is analyzed and monitored.Based on the theory of piezoelectric coupling, the bolts fastening type piezoelectrictransducer was selected as excitation source of the new type nebulizers, which couldprovide vertical vibration mode.(2) ANSYS is used to analyze the structure of the nebulizers based on thepiezoelectric coupling theory. Modal, harmonic response analysis and transient analysis isused to analyze the vibrating situation of the nebulizers. Based on the finite elementanalysis method, the vibrating mesh nebulizers’ nodal plane position is also analysed, theresults could be used for chose nozzle clamping position.(3) The structure composition, working principle of the spray system is introduced inthis paper. the influence and the reason of the bubble were analyzed when the mesh platewas in vibration. (4) The electronic balance and a video camera were used to catch the data of qualitychange in the working process of nebulizers. It was demonstrated that the flow rate wasaffected by the pore size and the viscosity of liquid, and the bubble was the main reason ofthe changes in the flow rate curve. Scanning electron microscopy (SEM) was chosen to todetermine the size of the water droplets in frozen state, and the particle size proved to bebetween5and20micrometers, suggesting a great potential for submicro-&nano-manufacturing.更多还原