【作者】 尚静；

【导师】 汪欣；

【作者基本信息】 吉林大学 ， 临床医学， 2013， 硕士

【摘要】 目的：分析喉癌术后并发咽瘘的相关因素，探讨喉癌术后发生咽瘘的原因，并针对原因提出防治措施。方法：回顾性分析吉林大学白求恩第一医院2008年1月至2012年12月收治的355例喉癌手术患者的完整临床资料。应用卡方单因素分析年龄、术前放疗、术前气切、喉癌分型、手术方式、临床分期、复发、基础疾病等因素与咽瘘发生的关系。结果：355例患者中有22例发生咽瘘，其发生率为6.20%，通过统计学分析结果发现与咽瘘发生的有相关性的因素有：患者术前放疗、术前气管切开、手术方式、临床分期、复发病例。结论：喉癌术后咽瘘发生的高危因素有：术前放疗、术前气管切开、手术方式、临床分期、复发病例。对于合并高危因素的喉癌患者，对患者术前、术中、术后可能引起咽瘘的各个环节充分认识、积极治疗，以期降低咽瘘的发生。更多还原

【Abstract】 Objection：To analyze the related factors,discuss the causes and prevention measures ofpharyngo-cutaneous fistula caused by laryngectomy.Methods:To retrospectively analyze the complete clinical data of355patients undergo laryngealcancer surgery from January2008to November2012in the first hospital of jilin university.To analyze the relationship between pharyngo-cutaneous fistula and the factors of sex, age,pre-operative radiotherapy, prior tracheotomy,tumor position, operation method,clinical stageof tumor,recurrence, comobidity with Chi-Square Test.Result:Among the355cases of laryngeal carcinoma,22cases were pharyngo-cutaneous fistulaafter operation, the incidence was6.20%. According to the statistical analysis results, thepredominant influencing factors in the causation of Pharyngo-cutaneous fistula are:pre-operative radiotherapy, prior tracheotomy, operation method,clinical stage oftumor,recurrence.Conelusion：The predominant influencing factors in the causation of pharyngo-cutaneous fistula are:pre-operative radiotherapy, prior tracheotomy, operation method,clinical stage of tumor,recurrence.For the laryngeal cancer patients with high risk factors, pay fully attention and takeactive treatments with the causes of pharyngo-cutaneous fistula in the preoperative, intra-operative and post-operative更多还原