【作者】 刘继文；

【导师】 张向阳； 李南方；

【作者基本信息】 新疆医科大学 ， 内科学， 2009， 硕士

【摘要】 目的：了解高血压病患者血浆中同型半胱氨酸水平与颈动脉厚度、性别、年龄、吸烟、饮酒、血糖、血脂的相关性。方法：抽取2007年3月-2008年3月在自治区人民医院高血压科住院患者250例。进行同型半胱氨酸水平、颈动脉内膜厚度及血脂、血糖检测,并对吸烟、饮酒相关危险因素调查,分为非高同型半胱氨酸组(≤15umol/L)和高同型半胱氨酸组(>15umol/L)进行分析。结果：①高血压患者血浆同型半胱氨酸水平随血压级别增高有增高趋势。②高同型半胱氨酸组与非高同型半胱氨酸组比较,右颈内动脉,左颈总动脉,左颈内动脉组中的IMT值高同型半胱氨酸组比非高同型半胱氨酸组高,P值均<0.05；性别分组后,男性中右颈总动脉、右颈内动脉、左颈总动脉、左颈内动脉组中的IMT值和女性中左颈总动脉、左颈内动脉的IMT值高同型半胱氨酸组比非高同型半胱氨酸组高,P值均<0.05。③相关分析显示,同型半胱氨酸与右颈内动脉内膜厚度、左颈总动脉内膜厚度、左颈内动脉内膜厚度正相关,P值均<0.05,与高密脂蛋白负相关,P值<0.05。结论：高血压患者血浆同型半胱氨酸水平与颈动脉厚度正相关、与高密脂蛋白负相关、随血压级别增高有增高趋势。更多还原

【Abstract】 objective:To understand the association of levels of plasma homocysteine in hypertensives with carotid artery thickness、gender、age、smoking、drinking、glucose and blood lipid.Methods:Select hypertensives 250 cases in March 2007-March 2008 in the People Hospital of Xin Jiang Autonomous Region, investigate of levels of plasma homocysteine, intima-media thickness(IMT), blood lipids, blood glucose, and smoking, drinking related risk factors, the subjects are divided into non-high HCY Group (≤15umol/L) and high HCY group(> 15umol/L).Results:①the levels of plasma homocysteine increased with hypertension in hypertensives②compare with high HCY group and non-high HCY group, the IMT of right internal carotid artery、left common carotid artery、left internal carotid artery are higher in high HCY group than non-high group, P<0.05; after divided by gender analysis, the IMT of right common carotid artery、right internal carotid artery、left common carotid artery、left internal carotid artery are higher in high HCY group than non-high group in male group, the IMT of left common carotid artery、left internal carotid artery are higher in high HCY group than non-high group in female group, P<0.05.③the levels of plasma homocysteine related positively with right internal carotid artery、left common carotid artery、left internal carotid artery, P<0.05, the levels of plasma homocysteine related negatively with HDL, P<0.05.Conclusion:The levels of plasma homocysteine are related positively with carotid artery thickness、negatively with high density lipoprotein and increased with hypertension in hypertensives.更多还原