【作者】 张海斌；

【导师】 何明霞；

【作者基本信息】 天津大学 ， 测试计量技术及仪器， 2010， 硕士

【摘要】 微球因具有易吸收,易游走,表面效应显著等特点,在临床医疗、微生物学和免疫学等领域得到了广泛应用。微球制备技术受到了制药界的关注,已成为了医药设备公司研发的热点方向之一。目前国内外的微球生产设备大都以生产毫米量级以上的微球为主,本研究采用超声破碎法来制取微球,微球粒径在微米量级。影响微球粒径大小的因素有:射流速度v、喷孔半径r、流体的粘度μ、超声振动的频率f等,论文核心工作是研究超声破碎制粒过程中的理论模型建立和关键技术的研究。建立了一套超声破碎式微球制备的实验性装置,其工作方式为:通过超声换能器将高频机械振动传递给药液射流,射流在这种振动的作用下,破碎成均匀液滴,经过凝结液后凝结成球。该装置由超声换能器、超声电源、喷孔、流速控制系统和载流系统组成。超声换能器的谐振频率为20KHz,研制了与之配套的电源,电源输出电压和频率连续可调,采用精密微型齿轮泵来控制射流速度,设计了具有流线型结构的喷孔,搭建了搅拌装置和微球测量分析装置。利用该装置做了大量超声破碎制粒实验,分析了射流速度v、喷孔半径r和流体粘度μ对超声制粒的影响。得到了本实验条件下射流破碎的最佳波长,适合超声破碎制粒的流速范围和喷孔半径范围以及射流破碎长度与射流速度之间的关系。通过理论分析,对卫星微球的产生原因进行了深入的研究,阐明了卫星微球的产生机理,并对射流破碎过程进行了模拟。更多还原

【Abstract】 The microspheres are widely used in clinical medicine, microbiology and immunology, because of it’s characteristics of absorption quickly, flow smoothly and surfcae effect. Microsphere preparation technology have been paid attention by pharmacy field and become a hotsport. In recent years, Most of production equipments produce microspheres in millimeter magnitude of microspheres at home and abroad. In this work, we use ultrasonic crushing technology to prepare microspheres size in micrometers. There are some influence factors to microspheres size, like as the jet speed v, nozzle radius r, the fluid viscosityμand ultrasonic vibration, etc. These mainly works are to construct a theoretical model and to study key technologies of ultrasonic crushing granulation method.We establish a set of ultrasonic experimental device of microsphere preparation, that’s working: the mechanical vibrations are delivered to the liquid jet through the high-frequency ultrasonic transducer so that the jet break into uniform droplets and laterly condensed into micro-ball. The device are consist of ultrasonic transducers, ultrasonic power, nozzle, flow rate control system and carrier system components. It’s transducer’s resonant frequency is 20KHz, the output voltage and frequency of power supply are adjusted continuously. In addition, precision micro-gear pump have been used to control the jet velocity and design a nozzle which has a streamlined structure. Also mixing system and measurements device of microsphere have been built.Using the device to do a lot of granulation experiments and to analyze the linfluence effect what caused by the jet velocity v, nozzle radius r and fluid viscosityμin the process of microspheres preparation. Having obtained the most appropriate wavelength of breakup, the range of jet velocity and nozzle radius for the current experiment. In other ways, have analysis causes to form satellite microspheres with correspondence theory in-depth, to clarify the generation mechanism of satellite microspheres, and have simulateed process of jet fragmentation.更多还原