【作者】 刘鹏；

【导师】 欧细平；

【作者基本信息】 中南大学 ， 心血管内科， 2011， 硕士

【摘要】 目的：观察代谢综合征患者脂联素、内脂素、超敏CRP的变化及瑞舒伐他汀对代谢综合征患者脂联素、内脂素、超敏CRP的影响,探讨瑞舒伐他汀对代谢综合征患者炎症因子的影响。方法：入选正常对照组21例；代谢综合征患者53例,随机分为试验组27例(常规降压治疗基础上加服瑞舒伐他汀钙,10mg／晚)和试验对照组26例(常规降压治疗),于治疗前及治疗后4-6周复诊时分别抽取外周血对脂联素、内脂素、超敏C反应蛋白等进行测定。结果：1.脂联素：试验组试验前和试验对照组试验前和试验后脂联素均低于正常对照组,组间差异有统计学意义(P<0.05)；试验组试验后脂联素比试验前高,差异有统计学意义(P<0.05)；试验组试验后脂联素比试验对照组试验后脂联素高(2组试验前差异无统计学意义),差异有统计学意义(P<0.05)；试验对照组试验后前脂联素的差值与试验组试验后前脂联素的差值有差异且有统计学意义(P<0.05)。2.内脂素：试验组和试验对照组试验前及试验后内脂素均高于正常对照组1,组问差异有统计学意义(P<0.05)；试验组试验后内脂素比试验前低,差异有统计学意义(P<0.05)；试验对照组试验后内脂素比试验前高,差异有统计学意义(P<0.05)；试验组试验后内脂素比试验对照组试验后内脂素低(2组试验前差异无统计学意义),差异有统计学意义(P<0.05)；试验对照组试验后前内脂素的差值与试验组试验后前内脂素的差值有差异且有统计学意义(P<0.05)。3.超敏C反应蛋白(hs-CRP):试验组和试验对照组试验前及试验后超敏C反应蛋白(hs-CRP)均高于正常对照组,组间差异有统计学意义(P<O.05)；试验组试验后超敏C反应蛋白(hs-CRP)比试验前低,差异有统计学意义(P<0.05)；试验对照组试验后超敏C反应蛋白(hs-CRP)比试验前高,差异有统计学意义(P<0.05)；试验组试验后超敏C反应蛋白(hs-CRP)比试验对照组试验后超敏C反应蛋白(hs-CRP)低(2组试验前差异无统计学意义),且差异有统计学意义(P<0.05)；试验对照组试验后前超敏C反应蛋白(hs-CRP)的差值与试验组试验后前超敏C反应蛋白(hs-CRP)的差值有差异且有统计学意义(P<0.05)。4.相关性分析显示：内脂素和体重指数(BMI)相关系数为0.449,P=0.016,有统计学意义(P<0.05)结论：1.代谢综合征患者脂联素水平明显下降,超敏C反应蛋白(hs-CRP)和内脂素明显升高。2.内脂素和体重指数(BMI)呈正相关性,有统计学意义。3.瑞舒伐他汀可以使代谢综合征患者血清脂联素水平明显升高,血清内脂素和超敏C反应蛋白(hs-CRP)水平均降低,且均有统计学意义；内脂素与超敏C反应蛋白的变化趋势呈正相关,而与脂联素变化趋势呈负相关。更多还原

【Abstract】 Objective:To observe the changes of adiponectin, visfatin, high sensitivity C-reactive protein(hs-CRP) in patients with metabolic syndrome and the impact of rosuvastatin on them. To discuss the impact of rosuvastatin on inflammatory factors in patients with metabolic syndrome.Methods:21 patients were enrolled in normal control group,53 patients with metabolic syndrome were randomly enrolled into test group (27 patients were taking rosuvastatin calcium, 10mg/night on the basis of conventional antihypertensive therapy) and control group (26 patients were taking conventional antihypertensive therapy), Seperately blood samples were taken Before or 4-6 weeks after treatment to investigate adiponectin, visfatin, hs-CRP.Results:1. Adiponectin:The adiponectines of before the test group and before and after the control group were lower than the normal control group, The differences between the groups were statistically significant (P<0.05); The test group test adiponectin was higher than before the test and the difference was statistically significant (P<0.05);The adiponectin of the test group was higher than the group 3 after the treatment and the difference was statistically significant (P<0.05) (the difference of before the two groupes was no statistically significant); The adiponectin after treatment in the control group was statistically different compared with the test group (P<0.05)2. Visfatin:The visfatin of test group and control group were higher than normal control group,both before and after experiment differences between the groups were statistically significant(P<0.05); Thet test group test visfatin was lower than before the test, the difference was statistically significant (P<0.05); The control group test visfatin was higher than before the test, the difference was statistically significant (P<0.05); The visfatin of the test group was lower than the control group after the treatment and the difference was statistically significant (P<0.05) (the difference of before the two groupes was no statistically significant); The visfatin after treatment in the control group was statistically different compared with the test group. (P<0.05)3. High sensitivity C-reactive protein (hs-CRP):The hs-CRP of the test group and the control group were higher than normal control group, both before and after experiment differences between the groups were statistically significant (P<0.05); The test group test hs-CRP was lower than before the test, the difference was statistically significant (P<0.05); The control group test hs-CRP was higher than before the test, the difference was statistically significant (P<0.05); The hs-CRP of the test group was lower than the control group after the treatment and the difference was statistically significant (P<0.05) (the difference of before the two groupes was no statistically significant); The hs-CRP after treatment in the control group was statistically different compared with the test group (P<0.05)4. Correlation analysis showed:Visfatin and body mass index (BMI) correlation coefficient was 0.449, P=0.016, statistically significant (P<0.05)Conclusion:1. The level of adiponectin significantly decreased in patients with metabolic syndrome,but high sensitivity C-reactive protein (hs-CRP) and visfatin significantly increased. 2. Visfatin and body mass index (BMI) were positively correlated with statistical significance (P<0.05)3. Rosuvastatin can make serum adiponectin levels significantly increased but make serum visfatin and high sensitivity C-reactive protein (hs-CRP) levels reduced in patients with metabolic syndrome, and there differences were statistically significant;The high sensitivity C-reactive protein was positively correlated trend with the visfatin but was negatively correlated trend with adiponectin.更多还原