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中西医结合治疗大肠癌化疗相关性腹泻的临床研究

Clinical Research on Synthesized TCM Treatment for Chemotherapy-induced Diarrhea

【作者】 李静

【导师】 李世杰;

【作者基本信息】 成都中医药大学 , 中西医结合临床, 2010, 硕士

【摘要】 目的:评价中西医结合方案治疗化疗相关性腹泻患者的临床疗效。方法:按照随机对照分组的方法,根据辨证论治的原理将符合标准的化疗相关性腹泻患者中的脾虚湿困失摄者,分为中西医治疗组和西药对照组,两组均予以内科基础治疗。其中对照组予以口服易蒙停止泻,中西医治疗组予以易蒙停加我科自拟中药组方扶正止泻汤治疗。整个疗程为7天,观察两组在治疗过程中的临床症状、体征及血常规、生化、大便常规+隐血、大便培养等实验室指标变化,通过采用spssl7.0软件进行统计学分析,观察其是否具有临床治疗意义。结果:在药物起效时间,中西医治疗组与西医对照组比较,差异无统计学意义;但中西医治疗组在改善患者的腹泻次数、肠鸣音等临床表现、减轻腹泻程度、提高患者食欲及体力等综合疗效方面方面较西医对照组具有优势。结论:中西医结合方案治疗大肠癌化疗相关性腹泻具有较好的临床效果。

【Abstract】 Objective:To evaluate the integrated Chinese and Western medicine in the treatment of chemotherapy-related diarrhea in patients with clinical efficacy.Methods:Randomized control group in accordance with the method, according to the principle of syndrome differentiation would be consistent with the standard chemotherapy-related diarrhea patients in the spleen wet storm photo missing persons, is divided into Chinese and Western medicine treatment group and western medicine control group, two groups are to be the basis of medical treatment. In which oral administration of the control group to be easy to Mongolia to stop the plunge in Chinese and Western medicine treatment group to be easy to Mongolia to stop the proposed increase, I Bureau since Medicines side Fuzheng antidiarrheal decoction. The entire course of treatment for 7 days were observed during the treatment of clinical symptoms, signs, and routine blood test, biochemistry, stool routine+occult blood, stool culture and other laboratory indicators of change, through the use of statistical analysis software spssl7.0 to observe its whether the clinical significance.Results:In the drug effect time of medicine with Western medicine treatment group compared to control groups no significant difference; but Chinese and Western medicine treatment group in patients with diarrhea in improving the frequency of clinical manifestations such as bowel sounds, reducing the degree of diarrhea, compared with Western medicine has the advantage of the control group.Conclusion:Synthesized Traditional Chinese medicine in treating chemotherapy-related diarrhea (CID) has a good clinical effect.

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