【作者】 李勇；

【导师】 乌莉娅·沙依提；

【作者基本信息】 新疆医科大学 ， 中药学， 2010， 硕士

【摘要】 目的:观察芹菜根醇提物对肾性高血压大鼠血压的影响及心脏的保护作用,并探讨其降压机制。方法:建立两肾一夹(2K1C)肾性高血压模型,随机分为阴性对照组,模型组,芹菜根醇提物高、中、低剂量组和阳性对照(CAP)组,每日灌药1次,连续4个月根据体重随时调整给药量,定期测定大鼠尾动脉收缩压和舒张压。于末次给药后分离腹主动脉取血后,取心脏,测定左心室重(LVW)/体重(BW)比值,测定超氧化物歧化酶(SOD)活力,丙二醛(MDA),血管紧张素Ⅱ(AngⅡ) ,内皮素(ET)含量。结果:(1)测定大鼠血压,芹菜根醇提物各剂量组和卡托普利组均显著低于模型组,有显著差异(P<0.05),说明芹菜根醇提物具有明显的降压效果。芹菜根治疗组SOD活力明显升高,MDA含量明显降低(P <0.05)。芹菜根治疗组明显降低血浆ET含量(P<0.05),而芹菜根高剂量组明显降低血浆Ang-Ⅱ含量(P<0.05)。测定(LVW)/(BW)比值,芹菜根醇提物各剂量组和卡托普利组均显著低于模型组,有显著差异(P<0.05),芹菜根醇提物各剂量组与卡托普利组相比,有显著差异(P<0.05)。结论:芹菜根醇提物具有降低肾性高血压大鼠的血压和抑制左心室肥厚的作用。更多还原

【Abstract】 Objective:To investigate the antihypertensive effects of aqueous extract of the roots of Apium graveolens L and heart protection ,and the underlying mechanisms in renovascular hypertensive rats. Methods: Two-kidney one clip (2K1C) renal hypertension were randomly divided into negative control group, model group, aqueous extract of the roots of Apium graveolens L high, medium and low-dose group and the positive control (CAP) group, the daily perfusion for 4 months at any time adjust the dose according to weight capacity, periodic determination of rat tail artery systolic and diastolic blood pressure. After the last administration, after separation of the abdominal aorta blood, take heart, left ventricular weight (LVW) / body weight (BW) ratio, superoxide dismutase (SOD) activity, malondialdehyde (MDA), Angiotensin -II (AngⅡ), endothelin (ET) content. Results: The determination of blood pressure, aqueous extract of the roots of Apium graveolens L of each dose group and captopril group were significantly lower than the model group were significantly different (P <0.05), shows aqueous extract of the roots of Apium graveolens L has significant blood pressure effect. aqueous extract of the roots of Apium graveolens L treatment group was significantly higher SOD activity, MDA content was lower (P <0.05). aqueous extract of the roots of Apium graveolens L treatment group was significantly decreased plasma ET levels (P <0.05), and aqueous extract of the roots of Apium graveolens L plasma high-dose group were significantly lower Ang-Ⅱlevels (P <0.05). Determination (LVW) / (BW) ratio, aqueous extract of the roots of Apium graveolens L of each dose group and captopril group were significantly lower than the model group were significantly different (P <0.05), aqueous extract of the roots of Apium graveolens L with the card each dose group Topley group, were significantly different (P <0.05).Conclusion: aqueous extract of the roots of Apium graveolens L can depress blood pressure in hypertensive rats and inhibit left ventricular hypertrophy.更多还原