【作者】 李锐；

【导师】 胡建国；

【作者基本信息】 中南大学 ， 心胸外科学， 2010， 硕士

【摘要】 目的：探讨山西省晋东南地区食管癌患者的一般情况及食管癌的高发影响因素,为该地区制定食管癌综合防治措施提供理论依据。方法：以2009年山西长治和平医院246例食管癌手术患者为病例组,采用1：1配对病例对照研究方法,选取246个与之在年龄、性别、居住地等方面相匹配的正常人为对照组,分别进行问卷调查,对病例组一般情况如年龄、性别、职业等进行描述性分析,对与食管癌发病可能相关的影响因素与食管癌间的关系采用X2检验、条件logistic回归分析,探讨晋东南地区食管癌的高发影响因素。结果：1.246例病例中,男性145例,女性101例,男女性别比1.44：1,其中<50岁26人,50-59岁101人,60-69岁97人,≥70岁22人。男性的平均年龄为59.15±7.80岁,女性的平均年龄为58.66±8.11岁；2.病理类型以食管鳞癌为主,占95.12%(234／246)；食管鳞癌分布以中段为主；3.多因素条件logistic回归分析结果显示：饮酒、吸烟、食酸菜、食烫食是男性食管癌发生的危险因素,食酸菜、食烫食是女性食管癌发生的危险因素,进食速度慢及多吃新鲜水果是食管癌发生的保护因素。结论：1.山西省晋东南地区食管癌患者多见于50～69岁老年人,男女比例为1.44：1；食管癌患者主要以中段鳞癌为主；2.饮酒、吸烟、食酸菜、食烫食是本地区男性食管癌发生的危险因素,食酸菜、食烫食是女性食管癌发生的危险因素,进食速度慢及多吃新鲜水果是食管癌发生的保护因素。更多还原

【Abstract】 Objective:To investigate the general incidence and risk factors of esophageal cancer in southeastern area of Shanxi province, an area with high- morbidity of esophageal cancer in China, so as to provide theoretical basis for drafting comprehensive preventive measures for esophageal cancer in the area.Methods:246 patients with esophageal cancer operated in Changzhi peace hospital Shanxi province in 2009 were considered as case group, another 246 people with matched age, gender and residence were taken as control group. All respondents were surveyed by questionnaire. Descriptive analysis was adopted to analyze general situation of esophageal cancer such as age, gender and occupation, X2 and logistic analysis were adopted to analyze the risk factors of esophageal cancer.Results:1. In the 246 cases,145 patients were male and 101 female; the ratio of male/female was 1.44:1. Age distribution was:26 cases less than 50 years old,101 cases between 50～59ys,97 cases between 60～69ys and 22 cases more than 70ys. Mean age of male cases was 59.15±7.80ys while females 58.66±8.11ys.2. Squamous cell carcinoma was the main histologic type, accounting for about 95.12%(234/246); The distribution of the cancer location was mainly in the middle part. 3. Multivariate logistic regression analysis showed that risk factors of esophageal cancer were drinking, smoking, eating sauerkraut and hot food for male cases while for female cases were eating sauerkraut and hot food; Slower eating speed and more fresh fruits consumption were protective factors of esophageal cancer.Conclusion:1. Esophageal cancer was more frequent in people aged from 50ys to 69ys in the southeastern area of Shanxi province, the ratio of male/female was 1.44:1; Patients with esophageal cancer were mainly squamous cell carcinoma with the middle part location;2. Drinking, smoking, eating sauerkraut and hot food were the major risk factors for male cases while for female cases were eating sauerkraut and hot food; slower eating speed and more fresh fruits consumption were protective factors of esophageal cancer.更多还原