【作者】 董银龙；

【导师】 宋玉民；

【作者基本信息】 西北师范大学 ， 无机化学， 2008， 硕士

【摘要】 随着年龄的增长,心、脑血管疾病发病率明显上升,其中不少与血栓性栓塞相关,长期以来临床多选用华法灵治疗血栓性疾病。华法灵是一种重要的口服抗凝血药物,可抑制凝血酶原的生物合成,用以预防血栓。但其副作用是并发出血,抗凝的强度可影响出血的危险性。因此,通过研究华法灵的配合物来寻找低毒的治疗药物,对抗凝血药物的作用机理、药物筛选都有非常重要的意义。本论文主要由以下三部分组成:1.对华法灵和水杨酸的理化性质和药理作用进行了概括。华法灵在治疗血栓性疾病中,是重要的口服药物。微量金属元素在生物体内的重要性日益被人了解,金属配合物研究得到广泛重视,金属配合物在治疗疾病中也发挥重要作用。提高华法灵抗凝血性性能,降低其毒性,确立本课题选择华法灵配合物为研究对象。2.稀土与华法灵、水杨酸三元配合物的合成和抗凝血作用研究用氯化稀土与华法灵钠、水杨酸钠在不同介质中,制备了镧、钕、铕、钇四种稀土三元配合物,所试验各种制备方法均可获得恒定组成的配合物REL2L’·2H2O(HL=华法灵;HL’=水杨酸)。通过元素分析、红外光谱、核磁共振氢谱、X射线衍射、摩尔电导、电子吸收光谱和溶解性试验对配合物进行了表征。抗凝血试验表明稀土三元配合物具有优良的抗凝血性质。3.过渡金属与华法灵配合物的合成和抗凝血作用研究用过渡金属硝酸盐与华法灵钠在不同介质中,制备了铁、钴、镍、铜四种过渡金属华发灵配合物,所试验的各种制备方法均可获得恒定组成的配合物NanML3·2H2O(L=华法灵离子,n =0,1)。通过元素分析、红外光谱、摩尔电导、紫外光谱、热重和溶解性试验对配合物进行了表征。抗凝血试验表明过渡金属华法灵配合物具有一定的抗凝血性质。并对过渡金属华法灵、过渡金属水杨酸、稀土金属华法灵、稀土金属华法灵水杨酸配合物的抗凝血性质进行了比较。更多还原

【Abstract】 With the growth of age, Cardio-cerebral vascular diseases increased significantly and many of them associated with thrombosis embolism, for a long time warfrain act as the medical treatment. It is an important oral anti-clotting drug, which play the role of anticoagulant by inhibiting the biological synthesis of prothrombin. However, the intensity of anticoagulation may affect the risk of bleeding. Therefore, study on the complex of warfrain to find the low toxicity is very important to make clear of the mechanism and screen of these drugs.1. The physical and chemical properties of warfrain and salicylic acid was summarized. Warfrain is an important oral anti-clotting drug. Trace metal elements’s act in the body were cleared, metal complexes receive widespread study meanwhile it play an important role in treatment of desease. Enhances warfrain’s antithrombogenicity performance, reduce its toxicity, make sure the complex of warfrain is the object of study.2. The rare earth ternary complexes had been prepared with rare earth chlorides, warfarinanion sodium and sodium salicylate. Above complexes have constant composition of REL2L’·2H2O (L= warfarinanion; L’= salicylate) by different synthesized methods, and had been characterized by elemental analysis, IR, 1HNMR spectra, X-ray diffraction, molar conductivity, electronic absorption spectrum and solubility. The rare earth ternary complexes all have nice anticoagulant action in related experiments.3. The transition metal complexes have been prepared from transition metal nitrate and warfarinanion sodium and characterized by elemental analysis, IR,UV, thermal analysis, molar conductivity and solubility. Above complexes have a constant composition of NanML3·2H2O (L= warfarinanion, n =0,1) by different synthesized methods. The transition metal complexes all show anticoagulant action in related experiments. And the anticoagulant action of the metal complexes with warfarinanion and salicylate has been compared.更多还原