【作者】 李玲；

【导师】 王冬梅；

【作者基本信息】 新疆医科大学 ， 妇产科学， 2009， 硕士

【摘要】 目的:本研究旨在探讨新疆维吾尔族与汉族重度子痫前期孕妇器官受累特点及其与围产儿预后的关系。方法:对277例重度子痫前期患者的回顾性研究资料进行分析总结。将重度子痫前期患者以民族不同分为维族和汉族。分析比较两组之间一般临床资料,器官受累情况和并发症发生情况以及围产儿结局。结果:297例重度子痫前期患者中,两民族均以単器官损害为主,其中维族患者器官损害以胎盘和肾脏损害为主,而汉族则以胎盘、心脏和视网膜损害为主。在两脏器受损患者中,汉族以胎盘并子痫及胎盘并DIC为主,维族以胎盘并肾损害为主。在多器官受损患者中,维、汉族无明显差异。在器官受损者的胎儿及新生儿,维族患者的围产儿死亡率明显较汉族的增高,差异有统计学意义。而多因素Logistic回归分析,胎儿及新生儿死亡与孕妇器官受损的数目有关,两器官和多器官受损的胎儿及新生儿死亡率较单器官受累明显升高,其中以维族患者尤其明显。结论:本研究显示重度子痫前期的器官受损在维族和汉族之间存在明显的不同,个体及民族间等多因素和多基因可能决定着不同的病理机制。更多还原

【Abstract】 Objective:To analyze the clinical features of the organ damage of severe preeclampsia (S-PE) between Vygurs and Hans in xinjiang , and the relationship of the organ damage and preinatal outcomes.Methods:A postspective study was conducted in 297 pregnant women with severe preeclampsia . patients were divided into two groups according to different ethnicity : Vygurs group (n=124) and Hans group (n=173). The clinical data were evaluated. The relations between the pattern of organ damage and maternal outcomes and perinatal mortality and morbidities were analyzed.Results:The main organ damage of all 277 S-PE cases was the single organ systemic . two nationalities by single organ harm primarily, Uygur national minority patient organ harm by placenta and kidney harm primarily, but Han Nationality by placenta, heart and retina harm primarily. In two internal organs damage patient, Han Nationality by placenta and eclampsia and placenta and DIC primarily, Uygur national minority by placenta and kidney harm primarily. In multi-organ damage patient, Uygur, Han Nationality not obvious difference. In the organ damage’s embryo and the newborn, the Uygur national minority patients encircle the product mortality rate to compare Han Nationality’s markup obviously, the difference have statistics significance. But the multi-factor Logistic regression analysis, the embryo and the newborn dies the number which suffers injury with the pregnant woman organ related, two organs and the multi-organs suffer injury the embryo and the neonatal mortality rate single organ exhausts oneself elevates obviously, is especially obvious by the Uygur national minority patients.Conclusion:This research demonstration specific severe preeclampsia earlier period’s organ suffers damage between the Uygur national minority and the Han Nationality has the obvious difference, between the individual and the nationality and so on multi-factors and the polygenes is possibly deciding the different pathology mechanism.更多还原