【作者】 李伟；

【导师】 张钟爱；

【作者基本信息】 南京中医药大学 ， 中医内科学， 2009， 硕士

【摘要】 理论探讨:在中医理论指导下,结合中西医衰老及痰浊、瘀血研究进展,探讨痰浊、瘀血与衰老的相关性。认为随着年龄的增长脏腑功能衰退或紊乱,气血津液运行不畅,导致体内痰浊、瘀血病理产物逐渐形成、日渐增多;痰浊、瘀血形成后会对机体造成损害,影响脏腑功能,阻碍气血津液运行,体内代谢运化失常,有害物质不断在体内蓄积,促使和加速机体的衰老,发展到一定程度又会导致相关疾病,加速机体衰老进程甚至死亡。痰浊、瘀血是衰老过程中的病理产物,是人体衰老的标志;一旦形成必然会成为机体衰老的重要因素,痰浊、瘀血是人体衰老的重要机制之一。临床研究:目的:为提出中医之痰浊、瘀血与衰老相关学说提供科学依据。方法:1对40岁以上各年龄段共371人进行痰、瘀证型临床观察。2对其中一部分观察对象共151人检测衰老指标SOD、MDA。(分为四组:痰浊阻遏证组34人、血瘀证组42人、痰瘀相兼证组39人、非痰非瘀组36人)。结果:1随着年龄的增长痰浊、瘀血的发生率逐渐增加,老年人大多数有痰浊、瘀血存在。随着年龄的增长痰浊、瘀血同时发生呈增加趋势。2痰浊阻遏证组、血瘀证组与非痰非瘀证组SOD、MDA比较,P＜0.05,具有统计学差异。痰瘀相兼证组与非痰非瘀组SOD、MDA比较,P＜0.01,具有显著统计学差异。痰浊阻遏证组、血瘀证组SOD、MDA比较,P＞0.05,不具有统计学差异。痰瘀相兼证组与痰浊阻遏证组、血瘀证组SOD比较P＜0.05,具有统计学差异;MDA比较P＞0.05,不具有统计学差异。结论:1痰浊、瘀血与衰老密切相关,是人体衰老的标志。2痰浊、瘀血与衰老指标SOD、MDA密切相关。机体清除氧自由基的能力减弱,自由基生成多,脂质过氧化反应强,机体受损伤程度重是痰浊、瘀血损害机体导致衰老的机制之一。更多还原

【Abstract】 Theoretical research:Under the guidance of TCM theory , combined the past and current research on theories of TCM and Western Medicine theory toward senescence and theory of phlegm, blood stasis, to make an discuses on the relationship of phlegm、blood stasis and senescence. We believe that as age adds, the function of Zang and FU declines or disorders, gas> blood and body fluid can not run smoothly, and pathology products such as phlegm and blood stasis forms, that more and more following age adds. Once phlegm and blood stasis formed, they will make an bad affect on the body and the function of Zang and FU organ, obstacle the movement of gas、blood and body fluid, than body metabolism disordered, hazardous substances continue to accumulate in the body,so that urging and accelerating body senescence ,phlegm、blood stasis developing to some extent can cause disease and accelerating the process of aging ,even the approaching of death. Phlegm and blood stasis are products of the process of aging, At the same time , they are the symbolism of aging. Once they are formed , the will become promoting reseat of aging, Phlegm and blood stasis are one of important mechanism of body senescence.Clinical research:Objective: Disgusting the the relationship of phlegm、blood stasis and senescence by clinically to provide clinical foundation for phlegm, blood stasis and aging-related theory of Chinese medicine.Method :1 To make clinical observation of the syndrome of phlegm and blood stasis towards 371 individuals(over 40-year).2 151of the individual motioned above will be tested the contraction of SOD and MDA.(devided into 4 groups: 34 for phlegm syndrome group, 42 for blood stasis group, 39 for phlegm combine with blood stasis syndrome group, 36 for non phlegm or stasis group ).Result: 1 As age growth, the accordance of phlegm and stasis increase as well,They appears in most old people. As age growth, the chance of acquired phlegm and stasis at the same time increase.2 Compare with non phlegm or stasis group, the value of SOD , MDA of phlegm syndrome group and blood stasis group has statistic difference(P<0.05). Compare with non phlegm or stasis group, the value of SOD , MDA of phlegm combine with blood stasis syndrome group has remarkable statistic difference(P<0.01). Compare with phlegm group, the value of SOD , MDA of blood stasis syndrome group don not has statistic difference(P>0.05). Compare with phlegm group and blood stasis group, the value of SOD of phlegm combine with blood stasis syndrome group has statistic difference(P<0.05), while the value of MDA do not has statistic difference(p> 0.05).Conclusion:1 The relationship of phlegm、blood stasis and senescence is closed, phlegm and blood stasis are the symbolism of senescence.2 Phlegm , blood stasis closely related to the value of SOD and MDA. The body’s ability to remove oxygen free radicals decreased and produce much oxygen free radicals, lipid peroxidation reaction process to much, make an serious bad affect on the body is a mechanism of how phlegm and blood stasis lead the body to aging.更多还原