【作者】 刘平；

【导师】 汪凯；

【作者基本信息】 安徽医科大学 ， 神经病学， 2009， 硕士

【摘要】 目的从认知神经心理学的角度,探讨表征时间信息的特异性神经定位。通过小脑损伤患者对不同长短时间知觉的研究,探讨小脑可能参与时间感知加工的机制。方法采用时距复制任务,对26例小脑损伤患者与年龄、利手及受教育程度相匹配的健康对照者的时间知觉能力进行研究。实验包括以视觉目标形式持续呈现的3段标准时间(短时距:0.6秒;长时距3秒和5秒),呈现结束后,延迟1s或5s进行时距复制,电脑自动记录复制结果。结果小脑损伤组与健康对照组均对0.6s有高估,而对3s和5s有低估;与健康对照组相比较,小脑损伤患者对600ms时距复制(延迟时间为1s和5s的复制结果分别为1.37±0.24,1.26±0.29)结果的差异均有统计学意义(Z=-5.347、-4.230,p<0.01);而与健康对照组相比较,小脑损伤患者对3s和5s的时距复制结果(延迟时间为1s和5s的复制结果分别为2.81±0.27, 2.78±0.29, 4.04±0.45, 4.19±0.35)的差异均无统计学意义(Z=-1.200、-0.092、-1.519、-0.723, p>0.05)。结论小脑损伤患者对时间信息的加工明显受损,主要表现在对短的瞬时时间的感知,这提示小脑可能特异性地参与了毫秒时间感知的认知加工。更多还原

【Abstract】 Objective The aim of this study was to discuss the nerve localization of characterization of time information from the perspective of cognitive neuropsychology, explore further the abilities of cerebellar lesions in skills of time estimation, and to test the hypothesis that cerebellum is involved in the special network of time perception.Method Time reproduction was required for three time intervals of 0.6 second, 3 and 5 seconds with visual discrimination for control. Participants reproduce those time intervals after 1-second or 5-second delaying. Computer recorded the results of reproduction automatically. Twenty-six patients with cerebellar lesions were compared to healthy controls, matched for age, handedness, education.Result 0.6-second was overestimated by both cerebellar lesions and healthy controls, however, both 3-second and 5-second were underestimated by them. Patients with cerebellar lesions were significantly impaired on 0.6-second reproduction task (delaying 1s or 5s, 1.37±0.24,1.26±0.29 respectively, Z=-5.347、-4.230,p<0.01). No group differences were found for the 3-second and 5-second time reproduction (delaying 1s or 5s , 2.81±0.27, 2.78±0.29, 4.04±0.45, 4.19±0.35 respectively, Z=-1.200、-0.092、-1.519、-0.723, p>0.05).Conclusion The findings suggest that patients with cerebellar lesions perform poorly during measurement of the shorter interval, but show no impairment of longer intervals perception, supporting the hypotheses that cerebellum is specifically involved in the perception of sub-second intervals.更多还原