膝关节疼痛机制与治疗现状研究及塞来昔布胶囊治疗关节镜手术临床疼痛效果的初步研究

【作者】 李磊；

【导师】 陈世益； 李云霞；

【作者基本信息】 复旦大学 ， 运动医学， 2009， 硕士

【摘要】 目的:评价塞来昔布胶囊在关节镜手术围手术期镇痛效果。方法:明确诊断具有半月板损伤患者78例(男46例,女32例,平均年龄31.39岁),前交叉韧带(ACL)损伤患者73例(男性48例,女性25例,平均年龄30.64岁),分别按照不同的围手术期用药剂量和方法分为3组:常规剂量;首剂增倍;空白对照组,并于术后3天分别测取VAS评分值,作统计检验分析。结果:半月板损伤治疗组VAS于3天评分均明显降低(P<0.01),ACL损伤治疗组VAS评分术后首日未见明显降低(P>0.05),第3天效果明显降低(P<0.01)。结论:塞来昔布胶囊对于关节镜手术围手术期镇痛效果有限,对于大型手术往往需要联合其他药物才能达到理想效果,并受术程影响。更多还原

【Abstract】 Objective:To investigate the pain killing effect of Celebrex adjustment to patients during arthroscopic surgery.Methods:78 patients(M 46,F 32,Average age 31.39) who had been diagnosed of meniscus injury were divided into three groups:normal dose,double dose and blank to collect the VisualAnalog Scale(VAS) value for 3 days after surgery,so does the other 73 patients(M 48,F 25,Average age 30.64) who had been diagnosed of ACL injury.Results:In the meniscus group,the VAS values decreased remarkably(P＜0.01) both immediately after the surgery and 2 days later.In the ACL group,the VAS values did not decrease remarkably(P＞0.05) immediately after the surgery,while 3 days later,it decreased remarkably(P＜0.01).Conclusion:Celebrex’s effect on pain killing is limited and it should be combined with some other method to relax the patients feeling during arthroscopic surgery.The result also showed a sign of time-related effect.更多还原