【作者】 滕菲；

【导师】 钟惠民； 陈昌祥； 刘海洋；

【作者基本信息】 青岛科技大学 ， 海洋化学， 2009， 硕士

【摘要】 本论文对两种金粟兰属植物,及己(Chloranthus serratus)和多穗金粟兰(Chloranthus multistachys)的化学成份进行了研究。综合运用薄层色谱(TLC)、制备薄层色谱(PTLC)、硅胶柱色谱(CC)、凝胶(Sephadex LH-20)色谱、反向柱层析(ODS)和高压液相色谱(HPLC)等色谱分离方法,UV、IR、MS和NMR等波谱分析方法,分离鉴定了20个化合物,其中新化合物8个,化合物类型为倍半萜和乌药烷型倍半萜二聚体。此外,本论文还对倍半萜二聚体的研究进展进行了综述。本论文从金粟兰属植物中分离得到的32个倍半萜二聚体和从其它属植物中分离得到的151个倍半萜二聚体在结构类型和生物活性方面进行了综述。及己(Chloranthus serratus)为金粟兰属植物,为我国传统中药,具有清热解毒,消肿止痛的功效。对采自湖南新宁的及己金粟兰的化学成分进行了研究,从中分离鉴定了16个化合物,包括6个乌药烷型倍半萜二聚体化合物,其中6个为新化合物(化合物3、8、9、10、14、15)。多穗金粟兰(Chloranthus multistachys)为金粟兰属植物,为我国传统中药,具有活血化淤的功效,民间主要用于治疗跌打损伤。对采自湖南新宁的多穗金粟兰的化学成分进行了研究,从中分离鉴定了4个乌药烷型倍半萜二聚体化合物,其中2个为新化合物(化合物3、4)。更多还原

【Abstract】 This dissertation elaborated the studies on chemical constituents of two plants which belong to the family of Chloranthus, Chloranthus serratus and Chloranthus multistachys. From above two plants, a total of 20 compounds were isolated by the chromatographic methods (including TLC, PTLC, CC, Sephadex LH-20, ODS and HPLC) and spectroscopic methods (including UV, IR, MS and NMR). Among them, 8 compounds were elucidated to be new ones , including four new eudesmane sesquiterpenoid lactones and four new lindenane sesquiterpene dimers. And sesquiterpene dimmers and their activity were summarized in the dissertation.Compounds isolated from the genus of Chloranthus and other plants and main physiological functions of them are reviewed.Chloranthus serratus belongs to the family of Chloranthaceae. Its rhizome has used as a treatment for ulcer and piles in traditional medical practice. Some chemical studies have been conducted before. In order to further search bioactive compounds, we investigated chemical constituents of Chloranthus serratus. As a result, six new compounds (3, 8, 9, 10, 14, 15) along with ten known ones were isolated. These compounds were identified as follows, and their structures are illustrated in Fig. A. glechomanolid (1) neolitacumone B (2) serralactone A (3)*1β,4β-dihydroxy-5αH- eudesman-7(11)-en-8α,12-olide (4) zedoalactone A (5) oplodiol 2a (6) cyperusol C (7) serralactone B (8)* serralactone C (9)* serralactone D (10)*3-eudesmene-1β,7,11-triol (11)4(15)-eudesmene-1β,7,11-triol (12) shizukaol B (13) shizukaol P (14)* shizukaol Q (15)* tianmushanol (16)。Chloranthus multistachys belongs to the family of Chloranthaceae. Its roots were applied to treat bone fracture in China as folklore medicine. Some chemical studies have been conducted before. In order to further search bioactive compounds, we investigated chemical constituents of Chloranthus multistachys. As a result, two new compounds (3, 4) along with two known ones were isolated. These compounds were identified as follows, and their structures are illustrated in Fig. B. shizukaol C (1) shizukaol D (2) chloramultilide E (3)* chloramultilide F (4)*。更多还原