【作者】 康飞；

【导师】 吕华冲；

【作者基本信息】 广东药学院 ， 药物化学， 2007， 硕士

【摘要】 本论文主要对大戟科药用植物白背叶(Mallotus apelta)的化学成分进行了系统的研究,同时对白背叶植物的化学成分及药理作用研究进展进行了综述。白背叶(Mallotus apelta)为大戟科(Emphorbiaceae)野桐属植物,叶和根均可入药,具有多种生理活性,如抗菌、抗病毒、止血作用、保肝作用等。临床报道白背叶的水煎剂对上消化道出血有很好的疗效,其作用与云南白药无显著差异,且无毒性。药理研究表明其制剂对多种致病性球菌、杆菌有明显抑制作用及杀灭作用。白背叶的全草中主要含有黄酮、三萜、二萜、香豆素、苯并吡喃、挥发油类化合物。为了从中分离得到更多的活性化合物,我们对其进行了系统的化学成分研究。从白背叶植物叶的水提物中分离得到10个化合物,经化学方法和波谱学方法(包括UV、IR、NMR、MS)鉴定了其中的9个化合物,依次为:大黄酚(Ⅰ),洋芹素-7-O-β-D-葡萄糖苷(Ⅱ),异东莨菪内酯(Ⅲ),β-谷甾醇(Ⅳ),芹菜素(Ⅴ),烟酸(Ⅵ),对甲氧基苯甲酸(Ⅶ),胡萝卜苷(Ⅷ),东莨菪内酯(Ⅸ).其中化合物Ⅰ,Ⅲ,Ⅵ,Ⅶ为首次从该植物中分离得到。更多还原

【Abstract】 This thesis focused on the chemical studies on Mallotus apelta, and also reviewed the progress of Mallotus apelta.Mallotus apelta, belongs to Mallotus genera of Emphorbiaceae family,has many biological activities, such as antibacterial, antiviral, anthemorrhagic and hepatoprotective effect. Both its roots and leaves are used an traditional Chinese medicine. It is proved to be more effective for upper gastrointestinal hemorrhage than tagamet in clinics. Modern pharmacological investigation indicates that it has the function to inhibit and kill a variety of pathogenic microbes and bacillus.The whole herb of Mallotus apelta contains flavonoids, triterpenoids, diterpenoid, coumarin, benzopyran, volatile oil compounds and so on. In order to isolate more active compounds, we have systematically investigated the chenmical constituents of the leaves of Mallotus apelta.10 compounds were isolated and 9 compounds were elucidated by chemical and spectroscopic methods(UV、IR、NMR、MS)as chrysophanol (Ⅰ), apigenin-7-O-β-D-glucoside(Ⅱ), isoscopletin(Ⅲ),β-sitosterol(Ⅳ), apigenin (Ⅴ), nicotinic acid (Ⅵ), 4-methoxybenzoic acid (Ⅶ),β-sitosterol-3-O-β-D-glucopyranoside(Ⅷ), scopoletin (Ⅸ).更多还原