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抑郁症患者细胞因子水平与心理状况的相关性研究
The Study of the Correlation between the Cytokines Level and the Mental Health State in Depression Patients
【作者】 党海红；
【导师】 何秉贤；
【作者基本信息】 新疆医科大学 ， 内科学， 2007， 硕士
【摘要】 目的:通过检测抑郁症患者血浆细胞因子水平,探讨细胞因子与抑郁症症状严重程度之间的关系。方法:收集2005年3月-2005年12月期间在新疆医科大学第一附属医院心身科住院的抑郁症患者39例。对所有患者均采用半定式精神检查,均符合国际疾病分类第10版(ICD-10)和中国精神障碍分类与诊断标准第三版(CCMD-3)中抑郁症的诊断标准,并且采用汉密尔顿抑郁量表17项评分均≥17分。选择38例心身健康的个体作为对照组。采用酶联免疫吸附法发(ELSIA)检测抑郁症组及对照组的血清白介素-2(IL-2)、白介素-6(IL-6)、肿瘤坏死因子-a(TNF-a)水平,并以汉密尔顿抑郁量(HAMD)进行评定。最后对测得的所有数据进行统计学检验分析。结果:抑郁症组与健康对照组年龄、文化程度及性别构成比之间无统计学差异(P＞0.05)。两组血清细胞因子浓度结果比较:抑郁症组血清IL-2、IL-6浓度均高于对照组(P＜0.05)差异有统计学意义。抑郁症组IL-2、IL-6、TNF-a与HAMD检测结果比较:抑郁症组IL-2、IL-6与HAMD总分呈正相关。结论:抑郁症患者存在细胞因子浓度改变;IL-6可能是抑郁症症状严重程度的生物学指标之一。
【Abstract】 Objectives:To investigate the correlation between the cytokines level and the severity of deprezzion by detecting the blood cytokines of deprezzion patients.Methods:39 impatients with depression were collected from March to december in 2005 in the first affiliated hospital of Xinjiang Medical Univercity.All patients were examinated by semi-structure mental state examination and all cases met the diagnostic criteria of ICD-10(the international classification of mental disorders) and CCMD-3(the Chinese Classification system of Mental Disorders)Then all patients were assessed with Hamilton Deprezzion Scale(HAMD) and theirs scores all atove 17.In addition,38 persons being mental and physical health were chosen as control groop.Blood samples were adopted for engyme-linked immuno-absorb assay to detect the level of blood interlenkin-2(IL-2),interlenkin-6(IL-6) and tumor mecrous factor(TNF-α)in both the test and control groops.Moreover,two groops were assessed by HAMD.In the end,all datas wer analyzed in statistical methods.Results:There was no significant difference of the age.education and gender between the deprezzion and the control groops.(p＞0.05) There was significant difference in plasma levels of ZL-2 and ZL-6 in two groops:the level of ZL-2 ZL-6 in test groop were more great them in control groop,(p＜0.05) and the difference has statistical significance.Also the HAMD scores indeprezzion groop were significantly great than the control groop.In addition,there was a positive correlation between IL-6 and HAMD scores.Conclusion:There was immune activation in depression patient,and the concentration of blood cytokines was abnormal.IL-6 may be a biological index which reflected the severity of Depression.