【作者】 李琳；

【导师】 王继良； 胡建林；

【作者基本信息】 昆明医学院 ， 药物化学， 2008， 硕士

【摘要】 2-吡啶甲酸是合成药物卡波卡因的关键中间体,也广泛应用于食品及染料等工业。2-甲基-1,4-萘醌(β-甲基萘醌,2-MNQ)是合成抗出血性药物维生素K的重要中间体,其分子中特殊的醌型结构,经酶的催化氧化,可产生抗癌作用。生物柴油是由可再生的油脂经合成得到的长链脂肪酸甲酯,是一种可替代普通柴油使用的环保燃油。介孔催化剂是以表面活性剂为模板,通过有机物和无机物界面作用组装生成的孔道结构规则、孔径介于2～50nm的无机多孔材料。其可重复利用及环保的特性,逐渐使之成为催化氧化领域的研究热点。我们以环保型双氧水为氧化剂,在这类新型介孔催化剂作用下顺利得到了2-吡啶甲酸和2-甲基-1,4-萘醌,且提高了反应的转化率或选择性。并在介孔材料的催化下高产率地得到了生物柴油。在2-吡啶甲酸的合成中,我们主要考察了反应温度、反应时间、氧化剂用量、催化剂用量、催化剂种类及溶剂种类对反应的影响,并进行了催化剂回收利用及元素分析实验,结果证实了我们所用的介孔催化剂是一种高性能、非均相的催化剂,在其催化下2-甲基吡啶的转化率可达98.2%,2-吡啶甲酸的选择性达92.8%,此实验有望为2-甲基吡啶高选择性地氧化制备2-吡啶甲酸提供一条高效、环保、经济、简单的合成途径。类似的方法也应用到2-甲基-1,4-萘醌及生物柴油的合成中,2-甲基萘的转化率为95.8%,2-甲基-1,4萘醌的选择性为69.3%;而生物柴油的收率为95.4%,都达到了预期的效果。更多还原

【Abstract】 2-pyridinecarboxylic acid is also called picolinic acid and is an important intermediate for synthesis of physiologically active substances, dyes,and other synthetic chemicals.It is prepared carbocaine in medical and pharmaceutical industry.The derivants are intermediate for phytocides and physiological drugs.Highly efficient catalytic oxidation of 2-methyl pyridine to 2-pyridinecarboxylic acid with mesoporous catalyst is a very important organic reaction.During catalytic oxidation of 2-methyl pyridine, we took advantage of a new type of catalyst—mesoporous catalyst.It can improved the conversion of 2-methyl pyridine and the selectivity of 2-PCA more than before.Meanwhile,the mesoporous catalyst was used into the preparation of biodiesel and vitamin K₃.The results show higher conversion or selectivity than before.During catalytic oxidation of 2-methyl pyridine,we mainly investigated reaction temperature、reaction time、concentration of oxidant、concentration of catalyst and type of solvents which effect on the reaction.At the same time, in order to validate the catalytic efficiency of catalyst,we carried out catalyst reclaim experiment and catalyst elemental analysis experiment.The results confirmed catalyst we have used was a type of high-powered heterogeneous mesoporous catalyst.Otherwise,we have undertook the experiments of recovery of 2-methyl naphthalene and 2-methyl-1, 4-naphthoquinone.The experiments certificated analytical methods which we have used were correct.In experiments,the conversion of 2-methyl pyridine was 98.2%,and the selectivity of 2-pyridinecarboxylic acid was 92.8%.The synthetic route of catalytic oxidation of 2-methyl pyridine to 2-pyridinecarboxylic acid over mesoporous catalyst would be a highperformanced、economic and simple method.In addition,we have used mesoporous catalyst successfully in the preparation of biodiesel and the synthesis of vitamin K₃.The yield of biodiesel was 95.4%,which can provide a new direction in reclaiming of bioenergy and solving the problem of lack of sources.The conversion of 2-methy lnaphthalene was 95.8%,and the selectivity of 2-methyl-1, 4-naphthoquinone was 69.3%,which will establish experiment foundation for study on synthesis of vitamin K-eae.更多还原