【作者】 肖强；

【导师】 王体沛；

【作者基本信息】 华中科技大学 ， 外科学， 2006， 硕士

【摘要】 目的:探讨人骨肉瘤组织中垂体肿瘤转化基因(PTTG)及c-myc蛋白在中的表达及其临床病理意义。方法:采用免疫组织化学的方法及图像分析技术检测37例骨肉瘤和12例骨软骨瘤中PTTG、c-myc蛋白的表达。并与骨肉瘤主要临床病理学参数及转移进行比较。结果: PTTG、c-myc在人骨肉瘤组织阳性表达率为67.568﹪,c-myc在人骨肉瘤组织阳性表达率为64.865﹪,且两者在骨肉瘤组织中的表达相关(P<0.05);而PTTG在骨软骨瘤中阳性率较低为8.33﹪,c-myc也较低为25﹪,而且两者阳性率转移组显著高于无转移组(P<0.05)。结论: PTTG的过表达可能是通过信号转导通路使c-myc表达增高促进骨肉瘤的发生、发展并与骨肉瘤预后有关。更多还原

【Abstract】 Objective: To investigate the relationship between expression of PTTG protein and that of c-myc protein and their role in oncogenesis of osteosarcoma .Methods: Immunohistochemistry (SP methods) was used to detect the expressions of PTTG protein and c-myc protein in 37 osteosarcoma and 12 osteoenchondroma.Results: PTTG and c-myc are both overexpress in the 37 cases of osteosarcoma (about: 67.568﹪、64.865﹪) while not in the 12 cases of osteoenchondoma (about: 8.33﹪、25﹪). And the expression of protein of PTTG、c-myc in the osteosarcoma same to be correlation(p<0.05).Conclusion: Over expression of PTTG and c-myc proteins maybe related to human osteosarcoma. And it is samed that the PTTG induced the osteosarcoma through the“c-myc way”.更多还原