【作者】 张少崇；

【导师】 李灿东；

【作者基本信息】 福建中医学院 ， 中医诊断学， 2007， 硕士

【摘要】 本文旨在从理论和流行病学调查两方面，研究中年人生理病理特点、证素规律以及性别之间存在的差异，探讨证素与生化指标之间的关系，将有助于进一步完善中年人生理病理理论，为中老年人保健，以及疾病的预防、治疗提供基础研究和新思路。(一)研究方法在理论研究基础上，采用流行病学调查研究和证素辨证相结合的方法，随机抽取313例“健康”中年体检者，进行四诊资料采集、证素辨证及血生化检测。(二)结果五脏病位中肝肾积分较之他脏具有显著性差异(p＜0.01)；病性证素中阴虚积分具有显著性差异(p＜0.01)；五脏辨证分型中肝阴虚、肝郁气滞较之其他证型具有显著性差异(p＜0.05)；不同性别间五脏病位差异性比较肝肾具有显著性差异(p＜0.01)；痰、湿证素与胆固醇和低密度脂蛋白呈正相关(p＜0.05)；阴虚证素与尿酸具有负相关(p＜0.05)；肝、肾证素与丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、尿素氮(BUN)无相关(p＞0.05)。(三)结论(1)中年人脏腑功能衰退以肝肾较为显著。(2)阴虚为中年人主要病理基础。(3)肝郁是中年人病理变化产生的重要环节。(4)七八以后男性肾虚呈上升趋势。(5)七七前、八七后女性肝肾衰退较显著。(6)中年女性脏腑衰退尤为明显。(7)中年人痰、湿证素和胆固醇、低密度脂蛋白，阴虚与血尿酸之间存在相关性，血液生化的改变可能是某些病性证素存在的生化基础之一。通过研究，从流行病学角度初步探讨了中年人证素分布的特点及性别之间的差异，从现代医学血液生化角度初步探讨了相关证素存在的病理基础。应用辨证积分方法进行辨证，为中老年人保健，以及中老年疾病的预防、治疗提供基础研究。同时对本课题存在的不足之处进行了讨论分析。更多还原

【Abstract】 In this paper the physiological and pathological feature, rule of symptom factorsdistribution and its sexual disparities of mid-aged people were studied, relations betweensymptom factors and biochemical indicator were analyzed, which were helpful to perfect theTCM theory of physiology and pathology, to make up insufficiency of syndromedifferentiation in latent syndrome and pre-syndrome, thus providing a basic research and newidea for the prevention, health protection and treatment for the mid-aged.Based on the theory research, 313 healthy mid-aged people were selected randomly aftermedical examination, whose symptoms and signs were collected and diagnosed by syndromedifferentiation based on symptom factors differentiation, and biochemical indicator weredetected. The result were: of the five zang organs, liver and kidney got a higher point thanother zang organs, indicating that liver and kidney were the mainly disease location ofmid-aged people; yin asthenia was significantly severer than other disease characters,indicating that yin asthenia was the capital nature of disease in this period; concerning thegenders, renal deficiency was distinguished after age 56 in man, while woman got a notablepathological change in liver and kidney before age 49 and after age 56, moreover woman wasmore severer in pathology than man; there were dependability between dampness, phlegm andbiochemical index in the mid-aged, while no correlation coefficients were foundbetween the liver, the kidney and certain biochemical indicators(ALT,AST and BUN).directing that blood biochemistry might be used in explaining of symptom factors.Through the study, the feature of symptom-complex and its sexual disparities in mid-agedpeople were developed by epidemiological research, and relationship between blood biochemistry index and physiological- pathological foundation was also discussed in thisperiod, which provided a basic research for the prevention, health protection and treatment ofthe mid-aged. Some deficiencies of the research were also discussed in this paper.更多还原