【作者】 康晓征；

【导师】 林剑浩；

【作者基本信息】 北京大学 ， 外科学， 2007， 硕士

【摘要】 目的通过标准化的膝关节骨性关节炎(Osteoarthritis,OA)症状问卷内容、影像学资料实验方案及X线片阅片评分标准,对内蒙古自治区武川县中老年人群膝关节OA患病率进行流行病学调查,并将调查结果与Beijing OA Study调查结果进行比较。旨在发现中国不同地区调查人群膝关节OA患病率的差异,以进一步了解与OA发病有关的危险因素。方法此次调查采用整群抽样方法,以村委会为单位(每个村委会下设4～8个自然村),选取内蒙古自治区武川县农村地区5个村委会,调查对象入选标准为:所有年龄大于50岁的本地常驻居民。每位调查对象在家中或者被邀请到调查中心接受标准化问卷调查,之后会被请到当地的医学中心进行影像学检查以及体格检查。本次调查影像学骨性关节炎(Radiographic OA, ROA)诊断标准为一侧或双侧膝关节Kellgren & Lawrence (K/L)评分≥2级。症状性骨性关节炎(Symptomatic OA, SOA)的诊断标准为:1)调查对象曾有过膝关节疼痛症状,且持续至少一个月时间;2)患侧膝关节被诊断为ROA。通过计算估测出内蒙古自治区武川县农村地区中老年人群膝关节OA患病率,并与Beijing OA Study的数据进行比较。结果本次调查对象共计1030名(年龄大于50岁),其中男性506名,女性524名,实际应答率约90.2%。不同性别总的ROA与SOA患病率分别为男性10%(ROA)、7%(SOA),女性20%(ROA)、14%(SOA)。≥65岁不同年龄段的调查对象双侧膝关节严重的ROA与SOA患病率同Beijing OA Study相比均较高。结论在此次调查中我们发现内蒙古自治区武川县农村地区中老调查人群膝关节OA患病率要明显高于北京城区调查人群,其中女性调查人群尤甚。对于上述情况的解释可能为性别、增龄、绝经、体重、劳动强度以及工作姿势等众多因素综合作用的结果。更多还原

【Abstract】 Objective To estimate the prevalence of knee osteoarthritis (OA) in the Middle-Aged and Elderly Population in WuChuan Rural Area Inner Mongolia using standardized questionnaire and radiographic protocols. Compare the prevalence with that of Beijing OA Study to explore the epidemiological characteristic differences in different urban or rural areas of China, and pursue further on the etiopathogenisis and evidence of prevention and treatment for OA.Methods Local rural residents aged 50 years and above from 5 village boards by cluster sampling method were investigated by questionnaire, radiographic examination and physical examination. The ones whose radiographic examinations show K/L≥2 were diagnosis as ROA. Those who had knee symptoms for at least one month, with radiographic examinations K/L≥2, were diagnosis as SOA. Finally, we compare the survey data with that of Beijing OA Study.Results 1030 participants aged 50 years and above from 5 village boards had taken this survey, including 506 males, 524 females. The response rate was 90.2%. The total prevalence of knee OA in male and female was male 10%(ROA),7%(SOA),female 20%(ROA),14%(SOA), respectively. In the 65 years and above age group, the prevalence of severe ROA and SOA are all higher significantly than that of Beijing OA Study.Conclusions In this study, we found that the prevalence of knee OA in Wuchan rural area was higher than that of Beijing urban area, the prevalence difference of female was significant. Gender, age, menopause, body weight, the difference in urban and rural of intensity and pose in works might serve as risk factors.更多还原