【作者】 戴静；

【导师】 王华林；

【作者基本信息】 合肥工业大学 ， 生物化工， 2007， 硕士

【摘要】 论文较深入地研究了聚乳酸(PLA)的合成、PLA／骨粉杂化材料的制备及杂化材料的性能。采用两步法制备高分子量聚乳酸，探讨了催化剂、反应时间及温度等条件对聚乳酸产率与分子量的影响。利用辛酸亚锡+氯化铝作为双催化剂体系可以使丙交酯产率达到48％，聚乳酸制备产率达到92％。基于超声波分散技术，采用溶液共混法制备出系列PLA／骨粉杂化材料，并通过FT-IR，DSC、SEM等测试手段对相关产物进行表征。结果显示，骨粉在PLA基质中分散均匀，与PLA基质间以氢键结合，相容性良好。与纯PLA材料相比，PLA／骨粉杂化材料的耐温性能明显提高。杂化材料在37℃的生理盐水中的降解试验结果表明，PLA／骨粉杂化材料降解11周后，呈三维立体支架结构，利于血管及骨细胞黏附长入；由于骨粉的引入，使PLA降解的酸性产物在一定的程度上得到中和，可以减小因PLA酸性过高引发的炎症反应，便于细胞增殖和组织修复；此外，由于骨粉具有天然骨中所有的无机离子，这些无机离子随着PLA／骨粉杂化材料的降解而逐渐释放，也为新骨的再生提供了丰富的必要元素。更多还原

【Abstract】 The synthesis and characterization of poly lactic acid (PLA) and PLA/bone dust hybrid materials were studied in this paper.PLA with high molecular weight was synthesized with two-step method. The effects of catalyst, reaction time and temperature on yield and molecular weight of PLA were investigated. Yields of lactide and PLA were 48% and 92% respectively with Tin( II) octanoate and aluminium chloride as catalysts.Based on ultrasonic dispersion technique , series of poly lactic acid(PLA)/bone dust hybrid materials were prepared by solution mixing method, and the relative result products were characterized by DSC, FT-IR and SEM. The results indicated that bone dust dispersed equally in PLA matrix and combine with matrix by hydrogenous bonds. Compare with pure PLA material, the heat resistance of PLA/bone-dust material was improved obviously. The invitro degradation of hybrid materials was conducted in normal saline at 37℃. The results showed that after the PLA/bone dust hybrid material degraded in saline for 11 weeks, a three-dimensional porous scaffold was obtained, this character scaffold is available for the growth of cells and blood vessel; because of the presentation of bone dust, the acidity products derived from degradation of PLA could be neutralized at a certain degree, which could decrease the inflammation chance and was beneficial to proliferation of cell, tissue repairing; moreover, bone dust include all inorganic ions of inartificial bone and these ions could gradually release with the degradation of PLA/bone dust hybrid material, this process provides abundant required element to regeneration of bone.更多还原