【作者】 黄珠；

【导师】 顾扬顺；

【作者基本信息】 浙江大学 ， 眼科学， 2007， 硕士

【摘要】 目的：通过报告骨髓移植术后慢性移植物抗宿主病(cGVHD)所致的眼表病变，探讨此类疾病的发病机制、诊断标准和治疗措施，提高临床诊断、治疗和预防能力。临床资料：患者，女，31岁，有慢性粒细胞白血病(CML)病史，在大剂量的化学治疗预处理后行亲缘异基因骨髓移植，移植后3月余出现cGVHD，眼部症状为双眼发干，畏光，视力下降。眼科检查提示严重的干眼症，以后有进展性角膜血管化、结膜化，药物治疗无效。结论：对于有cGVHD病史的病人，医生在移植术后需特别重视干眼症的诊断和治疗措施，以免角膜出现血管化和结膜化。血液科医生和眼科医生合作是治疗cGVHD的眼表病变所必需的。更多还原

【Abstract】 Purpose: To report a case with severe eye surface disease caused by chronic graft-versus-host disease (cGVHD), and try to find out the diagnostic criteria, pathogenesis and therapeutic measure of this disease.Thus, we can improve our competent.Clinical Data: A 31-year-old women with history of chronic myeloblastic leukemia, high-dose chemotherapy for eradication of hematopoietic stem cells, subsequent allogenic bone marrow transplantation, and eventually cGVHD was referred for dry eye, photophobia and decreased vision. Ocular examinations revealed severe dry eye that finally led to progressive corneal vascularization and conjunctival infiltration not responding tomedical therapy.Conclusion: In any patient with cGVHD, the physician should pay special attention to early diagnosis and treatment of dry eye before development of corneal neovascularization and conjunctival infiltration. Intimate collaboration of a salted ophthalmologist with the patient’s oncologist may be sight saving.更多还原