【作者】 缪婧；

【导师】 周长忍；

【作者基本信息】 暨南大学 ， 生物医学工程， 2006， 硕士

【摘要】 为了提高聚乳酸类材料的亲水性，调节其力学性能和降解性能，进而改善其生物相容性，本研究在制备的功能化聚乳酸和生物降解交联剂的基础上，采用多元共聚的方法，分别得到接枝共聚物、二元交联共聚物、三元交联共聚物材料，对其物理、化学性能进行了表征，并对其生物相容性进行了研究。 1．采用含羟基单体共引发丙交酯开环聚合，合成了末端双键功能化的聚乳酸大分子单体(PLA-HEMA)以及双乙烯基封端的生物降解交联剂(BCA)，通过FT-IR、~HNMR和GPC分析，结果表明合成了符合预期结构，分子量可调的聚乳酸大分子单体和生物降解交联剂。 2．采用溶液聚合法利用功能化聚乳酸大分子单体与N-乙烯基吡咯烷酮(NVP)按不同配比共聚，合成了具有亲水性PVP-PHEMA主链和疏水性PLA支链的两亲性接枝共聚物。FT-IR、~1H NMR、GPC分析结果表明，产物为预期结构的共聚物。对共聚膜材料的亲水性、生物相容性、降解性能研究结果表明，共聚物亲水性显著优于PLA，具有良好的血液相容性和组织相容性，对细胞生长无毒性，降解性能可通过共聚单体投料比进行调节。 3．利用双乙烯基生物降解交联剂(BCA)与聚乳酸大分子单体在紫外光引发下共聚合，制备了不同组成的二元交联共聚材料。通过固化时间和凝胶含量的测定对交联体系的反应过程进行了研究，FT-IR对交联材料进行结构表征，对膜材料的亲水性、吸水性及力学性能的研究结果表明，通过调节反应单体组成可获得不同分子结构和性能的二元交联共聚材料。 4．在前面工作基础上，通过紫外光引发大分子单体、生物降解交联剂、NVP三元本体共聚，制备了两亲性可降解交联材料。对交联材料的结构和性能进行表征，结果表明：通过调节反应单体组成，可控制材料的交联度，从而得到具有不同亲水性、吸水性和力学性能的支架材料，以满足构建不同组织对材料性能的具体要求；并可减少产物中小分子单体NVP残留量使其符合生物材料的使用要求。更多还原

【Abstract】 In this paper, in order to improve hydrophilicity of poly lactic acid(PLA), and adjust its mechanical property and degradability, then improve its biocompatibility, the double bond end-functionalized PLA macromonomers and biodegradable crosslinking agent was firstly synthesized, and then the graft copolymers, cross-linked copolymers and cross-linked terpolymers were prepared by multi-copolymerization. Then their physical and chemical properties were characterized, and their biocompatibilities were studied.1. PLA macromonomers and biodegradable crosslinking agent was synthesized. The results of FT-IR, ~1H NMR and GPC showed that the chemical structure and molecular weight of the polymers was consistent with the expectation.2. The amphiphilic graft copolymers were synthesized by copolymerization of the poly(D,L-lactide) macromonomer and N-vinyl pyrrolidone(NVP). The results of FT-IR, ~1H NMR and GPC showed that structure of the copolymers was consistent to the expectation. The results of the investigation on the hydrophilicity, biocompatibility and degradability indicated that compared to pure PLA, all the copolymers had higher hydrophilicity, good blood/tissue compatibility and non-cytotoxicity, their degradability could be regulated by feed molar ratios.3. A series of cross-linked copolymers were prepared by copolymerization of biodegradable crosslinking agent and PLA macromonomer initiated by ultraviolet(UV). The reaction process was studied by curing time test and gel content test. The results of FT-IR analysis, contact angle test, swelling ratio test and mechanical property test showed that chemical structure and properties of the cross-linked copolymer were changed with different feed molar ratios.4. Based on the research above, a series of cross-linked terpolymers were prepared by terpolymerization of macromonomer, biodegradable crosslinking agent and NVP initiated by UV. The results of characterizing on chemical structure and properties of the cross-linked terpolymer indicated that its cross-linking density could be adjusted by feed ratios, then its更多还原