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AD喷雾剂的药学研究

【作者】 张冬梅

【导师】 秦明珠;

【作者基本信息】 南京中医药大学 , 生药学, 2006, 硕士

【摘要】 白毛夏枯草是唇形科植物筋骨草属金疮小草植物Ajuga decumbens Thunb.的全草。本品性寒,味苦、甘。可清热解毒、化痰止咳、凉血止血。主治咽喉肿痛、肺热咳嗽、肺痈及毒蛇咬伤,跌打损伤等。临床多用于治疗气管炎、支气管炎、咽炎、高血压等疾病。 本课题运用现代技术,对白毛夏枯草的有效成份进行筛选,确定了有效成份并进行了制剂工艺研究,初步制定了此制剂的质量标准,主要内容如下: 1.对白毛夏枯草的n-BuOH部位进行成份分离、分析。运用硅胶柱,以二氯甲烷与甲醇的不同比例进行分离,得到两种化合物,经分析鉴定为8-o-acetylharpagide和harpagide,并进行了检测,8-o-acetylharpagide的纯度为98%以上,harpagide为不稳定化合物,纯度不好确定。 2.首次确定了harpagide为有效成分,且抗炎效果明显。 3.首次对白毛夏枯草及其成分8-o-acetylharpagide进行抗病毒作用的研究。 4.首次对白毛夏枯草进行了除杂工艺筛选,初步确定大孔树脂为最佳除杂工艺。 5.首次对大孔树脂工艺进行研究,找到实验室最佳制备条件。 6.首次按照《药典》要求,初步确定白毛夏枯草喷雾剂的质量标准草案。

【Abstract】 Bai Mao Xia Ku Cao (Ajuga decumbens Thunb.) Proberties: Bittet, Sweet, Cold; acting on the lung channel; to clear away heat and purge fire, to subdue swelling and remove toxic material, to relieve cough and dissolve phlegm. Indications: cough due to consumptive disease, trachitis, hemoptysis, epistaxis, sore throat, acute mastitis, acute appendicitis, traumatic injure.By using modern technology , we selected and oriented the valid composition of Ajuga decumbens. After the research of medicine preparation , the quality standard also has been established.The main contents are included bellow.1. We separated and analyzed the compounds in the n-BuOH part of Ajuga decumbens by column chromatography on Si gel eluted with CH2Cl2 containing increasing amounts of MeOH.Two compounds have been obtained and approved 8-o-acetylharpagide and harpagide by analysis, and the former’s purity was over 98%.2. We demonstrated firstly that harpagide, whose anti-inflammation effect present obviously, was a valid composition.3. We researched firtly the anti-virus effect of Ajuga decumbens and its component 8-o-acetylharpagide.4. We selected the technique of eliminating the impurity of Ajuga decumbens, and then ascertained macroporous resin as the best means.5. We researched firstly the technique of macroporous resin , and found the best laboratory condition of preparation.6. We studied out the quality standard draft of Ajuga spray in terms of Pharmacopoeia.

  • 【分类号】R283
  • 【下载频次】232
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