【作者】 任凌燕；

【导师】 李惠芝； 兰志银；

【作者基本信息】 重庆医科大学 ， 药物化学， 2006， 硕士

【摘要】 茅莓系蔷薇科悬钩子属植物茅莓Rubus parvifolius L.的干燥全草,是一味尚待开发的民间中草药。其性凉味苦,根、茎、叶均可入药,具有清热解毒、活血散瘀、凉血止血、祛风利湿、杀虫疗疮等功效,主治感冒发热、咳嗽咯血、痢疾、跌打损伤、产后腹痛、崩漏、外伤出血、疥疮、疖肿等多种疾病。目前,关于茅莓的文献不多,仅有一些关于其化学成分和药理作用方面的报道。本论文在文献研究的基础上,对茅莓进行了较为系统的形态组织学与质量控制研究,目的是为茅莓药材的质量控制及开发利用提供科学依据,为进一步制订茅莓药材及其相关新药制剂的质量标准提供理论依据。经历代本草及现代文献考证,茅莓药用历史悠久。在民间,其根、茎、叶均可入药;其果实,无论在古代还是现代,民间都曾将其误作覆盆子入药使用。本论文采用常规的性状及显微鉴别方法对茅莓全草进行了鉴定;同时,选择与茅莓皂苷类成分母核相似的齐墩果酸为对照品,以分光光度法对具有抗脑缺血作用的茅莓总皂苷进行含量测定;并运用溶剂提取、柱色谱、制备高效液相色谱等方法从茅莓全草中提取分离得到一皂苷类化合物（悬钩子皂苷R₁）。再以此为对照品,建立TLC法和更多还原

【Abstract】 Herb Rubi Parvifolii is the dried herb of Rubus parvifolius L.,genus Rubus in family Rutaceae.It is one of Chinese drugs used by the folks in common and yet waiting for development research about its value in use. Cold in nature, bitter in flavour, its root.stems and leaf are all used as the drug for clearing away heat and toxins, removing blood stasis and promoting blood circulation , removing heat from the blood to stop bleeding, dispelling wind-evil and wetness-evil , anthelmintic action, treating sores and so on in the treatment of common cold and fever,cough and hemoptysis, dysentery, wound, postpartum abdominal pain , metrorrhagia, scabies,sores etc.There are some materials about Herb Rubi Parvifolii just on its chemical compounds and pharmacological effects in recent years. So in order to provide a scientific basis for quality control and development research of Herb Rubi Parvifolii, as well as providing a theorical basis for darwing its quality standard, this thesis has systematically studied Herb Rubi Parvifolii in pharmacognosy and quality control on the basis of its materials.更多还原