【作者】 纪良霞；

【导师】 王立升；

【作者基本信息】 广西大学 ， 林产化学加工工程， 2006， 硕士

【摘要】 辣椒碱是辣椒中的主要呈辣物质，是一种香草酰胺类生物碱，因其在工农业生产上有重要的应用价值而对它的研究非常活跃。辣椒碱有多种药理作用，如镇痛、止痒、杀菌消炎等，并且以辣椒碱为原料的药用软膏已经成功推向市场。随着全球医药、轻化工和食品工业的迅速发展，国内、国际两个市场对辣椒碱的需求呈逐年上升趋势，市场供不应求。 关于辣椒碱的提取方法主要有乙醇法、丙酮法、酸碱法、超临界CO₂萃取法等，据报道Albright在利用细胞培养技术制备辣椒碱方面作了有益的尝试，Kaga用化学合成方法制备辣椒碱也获得了初步成功。 论文以广西指天椒为原料，经乙酸乙酯抽提、稀乙醇去除辣椒红色素、石油醚重结晶，得到白色针状晶体，经过GC-MS和HPLC分析检测为辣椒碱和二氢辣椒碱的混合物，二者含量之比为7∶3。 第一步的提取溶剂为乙酸乙酯。在单因素实验的基础上，通过正交实验优选了提取辣椒碱的最佳工艺，即：取一定质量的辣椒粉，加入4倍体积的乙酸乙酯，65℃，搅拌6h。 第二步的提取溶剂为80％乙醇。通过正交实验优化其工艺条件，得到的最佳条件为：取一定量的辣椒油树脂，加入6倍体积80％乙醇，在18-20℃提取3次，每次6h。 比较和分析了文献中辣椒碱的合成方法，设计一条简单易行的路线合成出辣椒碱，并经元素分析、质谱、红外光谱及¹H-NMR确证结构。更多还原

【Abstract】 Capsaicin is the essential pungent substance in the capsicum. It is a kind of vanilla-amide alkaloid. Because it is valuable in agriculture and industry, the research on it is flourishing. The capsaicin has many pharmacological activities, such as analgesia, relieving itching, sterilization anti-inflammation and so on, and the medicinal ointment prepared by capsaicin has been successfully pushed into the market. With the rapid development of the medicine, light and chemical engineering and food industry all over the world, the need for capsaicin in the domestic and international market has been increasing for years, the supply in the market falls short of demand.The extraction methods of capsaicin mainly contain ethanol method, acetone method, alkaline-acid method, supercritical carbon dioxide extraction method and so on. It was reported that Albright had tried on the preparation of capsaicin by cell culture techniques, Kaga made initial success in the synthesis of capsaicin by chemical method.In this paper a kind of white needle-like crystal was obtained via three steps更多还原