注射用丹参多酚酸盐治疗稳定型心绞痛（心血瘀阻型）的Ⅲ期临床研究

【作者】 金惠玲；

【导师】 刘永家；

【作者基本信息】 成都中医药大学 ， 中西医结合临床， 2006， 硕士

【摘要】 目的：观察注射用丹参多酚酸盐治疗稳定型心绞痛(心血瘀阻型)的有效性及安全性。 方法：对符合冠心病稳定型心绞痛心血瘀阻型诊断标准的80例患者采取随机分组、仿盲、阳性药平行对照设计，分为试验组1、试验组2与对照组共3组。试验1、2组用丹参多酚酸盐不同剂量治疗，对照组用丹参注射液治疗，疗程14天，观察治疗前后各症状记分及相关检查变化情况。 结果：(1)疾病综合疗效：14天后试验组1、试验组2与对照组组间两两比较差异无统计意义(P＞0.05)；(2)14天后心绞痛总疗效：试验组2与其余两组比较差异有统计意义(P＜0.05或P＜0.01)；(3)14天后中医症状疗效：试验组1、试验组2与对照组组间两两比较差异均有统计意义(P＜0.05或P＜0.01)；(4)14天后心电图疗效：试验组1、试验组2与对照组组间两两比较差异无统计意义(P＞0.05)；治疗后心绞痛及中医症状均较治疗前有改善；(5)安全性结果：治疗后一般体格检查、血常规及肝肾功未见异常。1例出现不良反应。 结论：注射用丹参多酚酸盐能改善稳定型心绞痛(心血瘀阻型)的临床症状，且比较安全。更多还原

【Abstract】 Objective: To investigate the clinical effect, security of Salvianolate injectionon stable angina of coronary heart disease of heart blood stagnation syndrome,and explore its mechanism .Methods: 80 cases of stable angina with heart blood stagnation syndrome wereobserved and randomly and averagely devided into treatment group 1, 2 andcontrol group. Treatment group were treated with Salvianolate injection, whilecontrol group were treated with Salvia miltiorrhiza Bge. injection. The period oftreatment was 14 days.the symptoms and signs were observed both before andafter treatment. The correlative eximations were taken both before and aftertreatment.Result: Effection of three groops and ECG was no significant difference (P>0.05). The total effection of angina after 14 days was significant difference in thetreatment group 2 and the others (P<0.05 or P<0.01) . The total effection ofsymptoms in Chinese was significant in the treatment groups and the controlgroup (P<0.05 or P<0.01) . The symptoms and signs, compared to these beforetreatment of the three groups got better obviously. Only one side effect wasfound.Conclusion: Salvianolate injection has obvious effect on stable angina of heartblood stagnation syndrome and more safety.更多还原