【作者】 祝侠丽；

【导师】 黄桂华； 张娜；

【作者基本信息】 山东大学 ， 药剂学， 2006， 硕士

【摘要】 目的：探索恶性肿瘤热疗和化疗协同治疗、并配合造影剂进行温度监控的新思路、新方法和新技术。恶性肿瘤即癌症是威胁人类健康的三大疾病之一，其特征为异常细胞的失控生长，并由原发部位向其它部位播散，侵犯要害器官和引起器官衰竭，最后导致死亡。 目前恶性肿瘤的主要治疗方法有：手术、放疗、化疗、免疫疗法及热疗等。其中化疗仍然是临床上治疗恶性肿瘤的主要方法之一，目前临床应用的化疗药物多数是常规剂型如注射剂，在杀灭癌细胞的同时亦杀灭大量正常细胞，因此毒副作用大，并发症多，治疗指数低，病人顺应性差。化疗治疗恶性肿瘤的关键是提高抗癌药物对癌细胞及组织、器官的靶向性，降低药物对正常细胞、组织和器官的毒副作用。肿瘤热疗被国际医学界称之为“绿色疗法”，温度是肿瘤热疗的核心。热疗中温度测量／显示是热疗中的重点和难点。传统的热疗测温方法多为点状测温，部位损伤大，难以反映温度分布的全貌并且常常引起感染、出血等并发症。将热疗与化疗联用，即在肿瘤局部加热并局部化疗，在尽可能减低药物用量的同时提高疗效，提高患者的生存率，减轻痛苦，改善患者的生活质量。 热敏脂质体是脂质体靶向制剂中一个很有发展前途的分支，将抗癌药物包封于热敏脂质体，在加热的肿瘤局部将其内含药物释放，达到靶向热化疗的目的。同时将造影剂包封于脂质体中，通过CT检查肿瘤部位造影剂浓度的变化，可正确显示肿瘤部位，从而有效地利用脂质体和热疗双重优势来提高肿瘤的治疗效果，避免全身化疗的副作用，更好地发挥热疗和化疗的协同作用，具有广阔的临床应用前景。 本文拟以L-α-二软脂酰磷脂酰胆碱(DPPC)为主要膜材，洛莫司汀为模型药更多还原

【Abstract】 Objective: To develop a new idea, new method and new technique for the purpose of temperature control by corporating thermotherapy, chemotherapy of cancer and the CT contrast agent together. The malignant tumor is one of the three kinds of diseases which do harm to human’s health, and is characterized by out-of-control growth of abnormal cells, which scatter from primary position to other positions, infiltrate critical organs, and at last cause the exhaustion ofnormal function and death.The main therapeutics of malignant tumor at present are operation, radiotherapy, chemotherapy, immunotherapy, thermotherapy et al. Chemotherapy is still the most important therapy method of the malignant tumor, though chemotherapy drugs used to have many side effects and the therapeutic index is very low. Targeting chemotherapy is the development direction. Thermotherapy is called "green therapy" in the international medical field. But the displaying and measuring of the temperature in the thermotherapy are important and difficulty. Almost all the traditional methods of temperature measuring are harm to patients and can only measure dot temperature, it is difficult to display all temperature distribution and cause many complications. To corporate thermotherapy with chemotherapy can raise the curative effect, introduce a non-harmful and accurate temperature measuring method and drop the dosage of the chemotherapy drug as low as possible, therefore to improve the patient compliance and the safety of the long-term treatment.Drug delivery systems can in principle provide enhanced efficacy and/or reduced toxicity for anticancer agents. Liposomes can exploit the enhanced permeability and retention effect for preferential extravasation from tumor vessels. Thermo-sensitive liposomes(TSL) is one of the promising branches of liposomes for cancer treatment. The anti-tumor drugs enveloped into TSL would release at the heated tumor tissues and achieve targeting chemotherapy, at the same time, the liposomaylation contrast agent更多还原