【作者】 张丽；

【导师】 李镜海；

【作者基本信息】 山东大学 ， 眼科学， 2006， 硕士

【摘要】 目的：波前像差引导的个体化切削是目前准分子激光角膜屈光手术发展的一个重要方向。人眼波前像差受多种因素的影响，特别是调节作用的影响。本研究目的是通过观察正视眼、低度近视眼、中度近视眼和人工晶体眼的波前像差，及调节作用引起的波前像差的改变，研究人眼波前像差的特征及调节作用对波前像差的影响。 对象和方法：采用根据Hartmann-Shack原理设计的WASCA波前像差仪，在6mm瞳孔直径分别测量64例正视眼和中低度近视眼(其中正视组9眼、低度近视组21眼、中度近视组34眼)及5例人工晶体眼在调节放松和调节状态的波前像差。主要观察指标包括总高阶像差、球差、水平慧差和垂直慧差，采用SAS9.0软件进行统计学分析。 结果： 1、自然晶体眼按照调节放松时的屈光度分组，结果见在调节放松状态，除球镜度外各组间的总高阶像差、慧差、球差均无显著差异；对所有指标进行多元线性相关分析，结果水平慧差和球差与总高阶像差存在线性相关(p值分别为0.0019、0.0008)，线性相关系数分别为r=0.3813、r=0.4090；左右眼别的高阶像差无显著差异。 2、在调节状态，各组间的总高阶像差、慧差、球差均无显著差异：调节前后进行配对t-检验，结果显示调节导致以下改变：(1)球镜度增加(p＜0.0001)；(2)球差减小(p＜0.0001)，并有向负值的方向改变的趋势，但并非每例受试眼的球差都变为负值：(3)调节作用能够产生明显的慧差和总高阶像差的改变。 3、人工晶体眼波前像差在调节前后的改变无统计学意义，人工晶体眼的高阶像差明显高于自然晶体眼。更多还原

【Abstract】 Objective : The wavefront aberration guided-customized ablation is an important part of the corneal refractory surgery . And the wavefront aberration(WA) can be affected by many factors, especially the accommodation. This study is to investigate the WA in emmetropia, myopia, patience with IOL, and the changes with accommodation. And to determine the characters of WA of human eyes and the influence of the accommodation to the WA.Methods : The WA of the 64 emmetropia and myopia(including 9 emmetropia, 21 mild myopia and 34 moderate myopia) and 5 eyes with IOL were measured with a Hartmann-Shack wavefront aberrometer(carl zeiss) in the state of unaccommodation and accommodation with the 6mm pupil diameter. The whole high order aberration (HOA),spherical aberration(SA),horizental coma and vertical coma were collected. Then analyzed the results with the software of SAS9.0. Results :1、 Classified the eyes by the degree of ametropia in the state of unaccommodation. There are no significant difference in the whole HOA, SA and coma in the state of unaccommodation. And the horizontal coma and the SA are correlated with the HOA(r=0.3813、r=0.4090). There is no significant difference in the WA of the left and the right eyes.2、There is also no significant difference of HOA, SA, and coma in the state of accommodation .Analyzed the date with and without accommodation .The results show:(1)The spherical diopters increase significantly (p<0.0001).(2)The SA更多还原